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Sprn
Gene Detail
Symbol

Name
ID
Sprn
shadow of prion protein
MGI:3582583
Synonyms
shadoo
Feature Type
protein coding gene
Genetic Map
Chromosome 7
85.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:140150628-140154877 bp, - strand
From VEGA annotation of GRCm38

  4250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84643  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Sprn

Human
homologs
Human Homolog SPRN, shadow of prion protein homolog (zebrafish)
NCBI Gene ID 503542
neXtProt AC  NX_Q5BIV9
Human Synonyms  bA108K14.1, SHADOO, SHO
Human Chr (Location)  10q26.3; chr10:133420666-133425163 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Mice homozygous for a knock-out allele exhibit normal survival but abnormal body weight.
 
Interactions
Sprn interacts with 296 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process protein import into nucleus
Component anchored component of membrane, cell, ...
Function nucleic acid binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (17)    Tissues (6)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
RT-PCR 12
cDNA source data(4)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000029041 (Evidence)
Ensembl Gene ModelENSMUSG00000045733 (Evidence)
Entrez Gene212518 (Evidence)
NIA Mouse Gene IndexU029421
Consensus CDS ProjectCCDS21966.1
International Mouse Knockout Project StatusSprn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029041 VEGA Gene Model | MGI Sequence Detail 4250 C57BL/6J ±  kb
transcript OTTMUST00000072058 VEGA | MGI Sequence Detail 3374 Not Applicable 
polypeptide OTTMUSP00000037005 VEGA | MGI Sequence Detail 147 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000015571 shadow of prion protein
References
(Earliest) J:98492 Premzl M, et al., Shadoo, a new protein highly conserved from fish to mammals and with similarity to prion protein. Gene. 2003 Sep 18;314:89-102
(Latest) J:199036 Toth E, et al., The highly conserved, N-terminal (RXXX)8 motif of mouse Shadoo mediates nuclear accumulation. Biochim Biophys Acta. 2013 May;1833(5):1199-211
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory