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Lemd3
Gene Detail
Symbol

Name
ID
Lemd3
LEM domain containing 3
MGI:3580376
Synonyms
Man1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
68.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:120923413-120979332 bp, - strand
From VEGA annotation of GRCm38

  55920 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8633  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LEMD3
Gene Tree: Lemd3

Human
homologs
LEMD3, LEM domain containing 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23592
neXtProt AC: NX_Q9Y2U8

Human Synonyms: MAN1

Human Chr (Location): 12q14; chr12:65169571-65248361 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human LEMD3

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(9) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in embryonic lethality at midgestation, defects in vascular remodeling and increased apoptosis in embryos, particularly in mesenchymal tissues.
 
Interactions
Lemd3 interacts with 343 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (14)    Tissues (7)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
In situ reporter (knock in) 5
cDNA source data(43)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lemd3    NEW 
Molecular
reagents
All nucleic(44) cDNA(43) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000031195 (Evidence)
Ensembl Gene Model ENSMUSG00000048661 (Evidence)
Entrez Gene 380664 (Evidence)
UniGene 339371
DFCI TC1672289, TC1673293, TC1641077
DoTS DT.40153228, DT.55281360, DT.526601
NIA Mouse Gene Index U069566
Consensus CDS Project CCDS48703.1
International Mouse Phenotyping Consortium Status Lemd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031195 VEGA Gene Model | MGI Sequence Detail 55920 C57BL/6J ±  kb
transcript OTTMUST00000077295 VEGA | MGI Sequence Detail 4370 Not Applicable 
polypeptide OTTMUSP00000040843 VEGA | MGI Sequence Detail 940 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(244 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018996 Inner nuclear membrane protein MAN1
InterPro IPR003887 LEM domain
InterPro IPR011015 LEM/LEM-like domain
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
Protein Ontology PR:000009755 inner nuclear membrane protein Man1
References
(Earliest) J:98702 Lin F, et al., MAN1, an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin. J Biol Chem. 2000 Feb 18;275(7):4840-7
(Latest) J:153986 Huber MD, et al., Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation. Mol Cell Biol. 2009 Nov;29(21):5718-28
All references(33)
Other
accession IDs
MGI:2143571

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory