Lemd3
Gene Detail

Symbol Name ID

Lemd3 LEM domain containing 3 MGI:3580376

Synonyms

Man1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

68.88 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr10:120923413-120979332 bp, - strand From VEGA annotation of GRCm38   55920 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8633  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Lemd3

Human homologs

Human Homolog		LEMD3, LEM domain containing 3
NCBI Gene ID		23592
neXtProt AC		NX_Q9Y2U8
Human Synonyms		MAN1
Human Chr (Location)		12q14; chr12:65563351-65642141 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human LEMD3

Alleles and phenotypes

All alleles(11) : Targeted(2) Gene trapped(9)
 

Homozygous mutation of this gene results in embryonic lethality at midgestation, defects in vascular remodeling and increased apoptosis in embryos, particularly in mesenchymal tissues.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	negative regulation of activin receptor signaling pathway, negative regulation of BMP signaling pathway, ...
Component	integral to membrane, integral to nuclear inner membrane, ...
Function	DNA binding, nucleotide binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (14)    Tissues (7)    Images (9)
Theiler Stages: 12

Assay Type	Results
RNA in situ	9
In situ reporter (knock in)	5

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) cDNA(43) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031195 (Evidence)
Ensembl Gene Model	ENSMUSG00000048661 (Evidence)
Entrez Gene	380664 (Evidence)
UniGene	339371
DFCI	TC1641077, TC1672289, TC1673293
DoTS	DT.40153228, DT.526601, DT.55281360
NIA Mouse Gene Index	U069566
Consensus CDS Project	CCDS48703.1
International Mouse Knockout Project Status	Lemd3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031195	VEGA Gene Model | MGI Sequence Detail	55920	C57BL/6J
transcript	OTTMUST00000077295	VEGA | MGI Sequence Detail	4370	Not Applicable
polypeptide	OTTMUSP00000040843	VEGA | MGI Sequence Detail	940	Not Applicable

All sequences(36) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(242 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018996	Inner nuclear membrane protein MAN1
InterPro	IPR003887	LEM domain
InterPro	IPR011015	LEM/LEM-like domain
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
Protein Ontology	PR:000009755	inner nuclear membrane protein Man1

References

(Earliest) J:98702 Lin F, et al., MAN1, an inner nuclear membrane protein that shares the LEM domain with lamina-associated polypeptide 2 and emerin. J Biol Chem. 2000 Feb 18;275(7):4840-7
(Latest) J:153986 Huber MD, et al., Overlapping functions of nuclear envelope proteins NET25 (Lem2) and emerin in regulation of extracellular signal-regulated kinase signaling in myoblast differentiation. Mol Cell Biol. 2009 Nov;29(21):5718-28
All references(35)

Other accession IDs

MGI:2143571