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Dgkk Gene Detail
Summary
  • Symbol
    Dgkk
  • Name
    diacylglycerol kinase kappa
  • Feature Type
    protein coding gene
  • IDs
    MGI:3580254
    NCBI Gene: 331374
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrX:6779306-6948363 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    523 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3580254
protein coding gene ChrX:6779306-6948363 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035506
protein coding gene ChrX:1407187-1526815 (+)
A/J MGP_AJ_G0035484
protein coding gene ChrX:1387542-1509899 (+)
AKR/J MGP_AKRJ_G0035417
protein coding gene ChrX:1447285-1579467 (+)
BALB/cJ MGP_BALBcJ_G0035480
protein coding gene ChrX:1412553-1533981 (+)
C3H/HeJ MGP_C3HHeJ_G0035188
protein coding gene ChrX:1440282-1561792 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036004
protein coding gene ChrX:1469383-1602845 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032879
protein coding gene ChrX:946207-1083138 (+)
CAST/EiJ MGP_CASTEiJ_G0034488
protein coding gene ChrX:1335343-1462849 (+)
CBA/J MGP_CBAJ_G0035158
protein coding gene ChrX:1560487-1689260 (+)
DBA/2J MGP_DBA2J_G0035315
protein coding gene ChrX:1426705-1546941 (+)
FVB/NJ MGP_FVBNJ_G0035262
protein coding gene ChrX:1374074-1508820 (+)
LP/J MGP_LPJ_G0035392
protein coding gene ChrX:1415562-1537356 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035301
protein coding gene ChrX:1525470-1658877 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036022
protein coding gene ChrX:1407312-1531161 (+)
PWK/PhJ MGP_PWKPhJ_G0034190
protein coding gene ChrX:1333403-1459419 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034027
protein coding gene ChrX:1339603-1467925 (+)
WSB/EiJ MGP_WSBEiJ_G0034611
protein coding gene ChrX:1402983-1529284 (+)



Homology
more
  • Human Ortholog
    DGKK, diacylglycerol kinase kappa
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DGKK, diacylglycerol kinase kappa
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 139189
    neXtProt AC: NX_Q5KSL6
    UniProt: Q5KSL6

  • Chr Location
    Xp11.22; chrX:50365407-50470850 (-)  GRCh38.p7

Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 331374 NCBI Gene Model | MGI Sequence Detail 169058 C57BL/6J ±  kb
transcript NM_177914 RefSeq | MGI Sequence Detail 7172 C57BL/6  
polypeptide NP_808582 RefSeq | MGI Sequence Detail 1118 C57BL/6  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • EC
  • InterPro Domains
    IPR037607 Diacylglycerol kinase
    IPR000756 Diacylglycerol kinase, accessory domain
    IPR001206 Diacylglycerol kinase, catalytic domain
    IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
    IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Molecular
Reagents
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  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 20
    Developmental Gene Expression 3
    Gene Ontology 2
  • Earliest
    J:115297 Crotty T, et al., Diacylglycerol kinase delta regulates protein kinase C and epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15485-90
  • Latest
    J:234101 Tabet R, et al., Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3619-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory