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Klf14 Gene Detail
Summary
  • Symbol
    Klf14
  • Name
    Kruppel-like factor 14
  • Synonyms
    5330411L03Rik, BTEB5
  • Feature Type
    protein coding gene
  • IDs
    MGI:3577024
    NCBI Gene: 619665
  • Gene Overview
    MyGene.info: KLF14
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:30956023-30959078 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3056 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.54 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KLF14, Kruppel like factor 14
  • Vertebrate Orthologs
    6
  • Human Ortholog
    KLF14, Kruppel like factor 14
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BTEB5
  • Links
    NCBI Gene ID: 136259
    UniProt: Q8TD94

  • Chr Location
    7q32.2; chr7:130732554-130734033 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display genome instability and increased tumor incidence with age. Mice homozygous for a conditional allele knocked out in the liver exhibit decreased circulating HDL cholesterol levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000014454 VEGA Gene Model | MGI Sequence Detail 3056 C57BL/6J ±  kb
    transcript OTTMUST00000034294 VEGA | MGI Sequence Detail 3056 Not Applicable  
    polypeptide OTTMUSP00000015356 VEGA | MGI Sequence Detail 325 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      6 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 2
      cDNA 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2141528
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:250752 Argmann CA, et al., Germline deletion of Kruppel-like factor 14 does not increase risk of diet induced metabolic syndrome in male C57BL/6 mice. Biochim Biophys Acta. 2017 Dec;1863(12):3277-3285

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory