Ano5
Gene Detail

Symbol Name ID

Ano5 anoctamin 5 MGI:3576659

Synonyms

Gdd1, Tmem16e

Feature Type

protein coding gene

Genetic Map

Chromosome 7

32.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:51511029-51598709 bp, + strand From NCBI annotation of GRCm38   87681 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:100071  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Ano5

Human homologs

Human Homolog		ANO5, anoctamin 5
NCBI Gene ID		203859
neXtProt AC		NX_Q75V66
Human Synonyms		GDD1, LGMD2L, TMEM16E
Human Chr (Location)		11p14.3; chr11:22214722-22304913 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human ANO5

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Component

endoplasmic reticulum, integral to membrane, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (5)    Tissues (3)    Images (1)
Theiler Stages: 22, 26, 28

Assay Type	Results
RT-PCR	5

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000055489 (Evidence)
Entrez Gene	233246 (Evidence)
DFCI	TC1591702, TC1592776, TC1594336, TC1626059
DoTS	DT.101290340, DT.111003422, DT.91279868, DT.94258834
NIA Mouse Gene Index	U008139
Consensus CDS Project	CCDS39968.1
International Mouse Knockout Project Status	Ano5

Sequences

Length	Strain/Species
genomic	233246	NCBI Gene Model | MGI Sequence Detail	87681	C57BL/6J
transcript	NM_177694	RefSeq | MGI Sequence Detail	7783	C57BL/6
polypeptide	Q75UR0	UniProt | EBI | MGI Sequence Detail	904	Not Applicable

All sequences(26) RefSeq(5) UniProt(1)

Polymorphisms

SNPs(435 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007632	Anoctamin/TMEM 16
Protein Ontology	PR:000004060	anoctamin-5

Graphical View of Protein Domain Structure

References

(Earliest) J:97748 Tsutsumi S, et al., The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). Am J Hum Genet. 2004 Jun;74(6):1255-61
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(27)