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Ano5 Gene Detail
Summary
  • Symbol
    Ano5
  • Name
    anoctamin 5
  • Synonyms
    Gdd1, Tmem16e
  • Feature Type
    protein coding gene
  • IDs
    MGI:3576659
    NCBI Gene: 233246
Location & Maps
more
  • Sequence Map
    Chr7:51511029-51598709 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      87681 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 32.76 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ANO5, anoctamin 5
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ANO5, anoctamin 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GDD1, LGMD2L, TMEM16E
  • Links
    NCBI Gene ID: 203859
    neXtProt AC: NX_Q75V66

  • Chr Location
    11p14.3; chr11:22192513-22283367 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 100071
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ANO5
  • Gene Tree
Human Diseases
more
  • Diseases
    3 with human ANO5 associations

Human Disease Mouse Models
       Gnathodiaphyseal Dysplasia; GDD   OMIM: 166260
Miyoshi Muscular Dystrophy 3; MMD3   OMIM: 613319
Muscular Dystrophy, Limb-Girdle, Type 2L; LGMD2L   OMIM: 611307
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000059013 VEGA Gene Model | MGI Sequence Detail 87681 C57BL/6J ±  kb
transcript OTTMUST00000144778 VEGA | MGI Sequence Detail 7785 Not Applicable  
polypeptide OTTMUSP00000075426 VEGA | MGI Sequence Detail 904 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    763 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    cDNA 5
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 25
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:97748 Tsutsumi S, et al., The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). Am J Hum Genet. 2004 Jun;74(6):1255-61
  • Latest
    J:198369 Suzuki J, et al., Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem. 2013 May 10;288(19):13305-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory