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Sp9 Gene Detail
Summary
  • Symbol
    Sp9
  • Name
    trans-acting transcription factor 9
  • Feature Type
    protein coding gene
  • IDs
    MGI:3574660
    NCBI Gene: 381373
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:73271926-73275771 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 43.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3574660
protein coding gene Chr2:73271925-73284706 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025834
protein coding gene Chr2:73540836-73553617 (+)
A/J MGP_AJ_G0025812
protein coding gene Chr2:70653591-70659137 (+)
AKR/J MGP_AKRJ_G0025780
protein coding gene Chr2:72591469-72604355 (+)
BALB/cJ MGP_BALBcJ_G0025806
protein coding gene Chr2:70841404-70853799 (+)
C3H/HeJ MGP_C3HHeJ_G0025566
protein coding gene Chr2:72780105-72794479 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026253
protein coding gene Chr2:75733840-75746891 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023656
protein coding gene Chr2:67855319-67868049 (+)
CAST/EiJ MGP_CASTEiJ_G0025030
protein coding gene Chr2:73041028-73056471 (+)
CBA/J MGP_CBAJ_G0025547
protein coding gene Chr2:78504537-78517298 (+)
DBA/2J MGP_DBA2J_G0025678
protein coding gene Chr2:70250402-70262673 (+)
FVB/NJ MGP_FVBNJ_G0025640
protein coding gene Chr2:69664164-69669710 (+)
LP/J MGP_LPJ_G0025766
protein coding gene Chr2:73417610-73430493 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025671
protein coding gene Chr2:80435499-80441045 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026310
protein coding gene Chr2:72678205-72683751 (+)
PWK/PhJ MGP_PWKPhJ_G0024771
protein coding gene Chr2:70166289-70179118 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024579
protein coding gene Chr2:72913909-72926669 (+)
WSB/EiJ MGP_WSBEiJ_G0025098
protein coding gene Chr2:73125656-73131206 (+)



Homology
more
  • Human Ortholog
    SP9, Sp9 transcription factor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SP9, Sp9 transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ZNF990
  • Links
    NCBI Gene ID: 100131390
    neXtProt AC: NX_P0CG40
    UniProt: P0CG40

  • Chr Location
    2q31.1; chr2:174335093-174337540 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele fail to thrive and exhibit general weakness and postnatal lethality associated with striatum atrophy and loss of striatopallidal medium-sized spiny neurons (MSNs) due to decreased proliferation of striatopallidal MSN progenitors and increased apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 381373 NCBI Gene Model | MGI Sequence Detail 3846 C57BL/6J ±  kb
    transcript NM_001005343 RefSeq | MGI Sequence Detail 2813 C57BL/6  
    polypeptide Q64HY3 UniProt | EBI | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 10
      Primer pair 1
      Other 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 12
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:95649 Kawakami Y, et al., Sp8 and Sp9, two closely related buttonhead-like transcription factors, regulate Fgf8 expression and limb outgrowth in vertebrate embryos. Development. 2004 Oct;131(19):4763-74
    • Latest
      J:264268 Li J, et al., Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development. Cereb Cortex. 2018 Sep 1;28(9):3278-3294

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory