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Serpinb3a Gene Detail
Summary
  • Symbol
    Serpinb3a
  • Name
    serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
  • Synonyms
    Scca2, Serpinb4, Sqn5
  • Feature Type
    protein coding gene
  • IDs
    MGI:3573933
    NCBI Gene: 20248
  • Gene Overview
    MyGene.info: SERPINB4
Location & Maps
more
  • Sequence Map
    Chr1:107045605-107052303 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6699 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 50.34 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SERPINB4, serpin family B member 4
  • Vertebrate Orthologs
    16
  • Human Ortholog
    SERPINB4, serpin family B member 4
    Orthology source: HomoloGene
  • Synonyms
    LEUPIN, PI11, SCCA1, SCCA2, SCCA-2
  • Links
    NCBI Gene ID: 6318
    neXtProt AC: NX_P48594

  • Chr Location
    18q21.3; chr18:63637259-63644319 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    3
  • Transgenic
    5
  • Genomic Mutations
    3 involving Serpinb3a
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit reduced susceptibility to allergen-induced airway hyperresponsiveness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021000 VEGA Gene Model | MGI Sequence Detail 6699 C57BL/6J ±  kb
transcript OTTMUST00000049647 VEGA | MGI Sequence Detail 1611 Not Applicable  
polypeptide OTTMUSP00000023036 VEGA | MGI Sequence Detail 387 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    83 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    Genomic 1
    cDNA 4

    Microarray probesets 7
References
more
  • Summaries
    All 22
    Gene Ontology 2
    Phenotypes 91
  • Earliest
    J:49294 Bartuski AJ, et al., A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases. Genomics. 1998 Dec 1;54(2):297-306
  • Latest
    J:216188 Sivaprasad U, et al., SERPINB3/B4 Contributes to Early Inflammation and Barrier Dysfunction in an Experimental Murine Model of Atopic Dermatitis. J Invest Dermatol. 2015 Jan;135(1):160-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory