Serpinb3a
Gene Detail

Symbol Name ID

Serpinb3a serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A MGI:3573933

Synonyms

Scca2, Serpinb4, Sqn5

Feature Type

protein coding gene

Genetic Map

Chromosome 1

50.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr1:107045605-107052337 bp, - strand From VEGA annotation of GRCm38   6733 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:76659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 4 cattle; 1 dog; 3 chicken

Protein SuperFamily: serpin
Gene Tree: Serpinb3a

Human homologs

Human Homolog		SERPINB4, serpin peptidase inhibitor, clade B (ovalbumin), member 4
NCBI Gene ID		6318
neXtProt AC		NX_P48594
Human Synonyms		LEUPIN, PI11, SCCA1, SCCA2, SCCA-2
Human Chr (Location)		18q21.3; chr18:61304493-61311502 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a knock-out allele exhibit reduced susceptibility to allergen-induced airway hyperresponsiveness.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component	extracellular region
Function	serine-type endopeptidase inhibitor activity

External Resources: FuncBase

Expression

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) Genomic(1) cDNA(4)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000021000 (Evidence)
Ensembl Gene Model	ENSMUSG00000044594 (Evidence)
Entrez Gene	20248 (Evidence)
UniGene	482944
DoTS	DT.101376264
NIA Mouse Gene Index	U021665
Consensus CDS Project	CCDS15214.1
International Mouse Knockout Project Status	Serpinb3a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021000	VEGA Gene Model | MGI Sequence Detail	6733	C57BL/6J
transcript	OTTMUST00000049647	VEGA | MGI Sequence Detail	1645	Not Applicable
polypeptide	OTTMUSP00000023036	VEGA | MGI Sequence Detail	387	Not Applicable

All sequences(22) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(79 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family

References

(Earliest) J:49294 Bartuski AJ, et al., A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases. Genomics. 1998 Dec 1;54(2):297-306
(Latest) J:189949 Sivaprasad U, et al., A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan;127(1):254-61, 261.e1-6
All references(24)