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Serpinb3a Gene Detail
Summary
  • Symbol
    Serpinb3a
  • Name
    serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
  • Synonyms
    Scca2, Serpinb4, Sqn5
  • Feature Type
    protein coding gene
  • IDs
    MGI:3573933
    NCBI Gene: 20248
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:107045587-107052303 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 50.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    83 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3573933
protein coding gene Chr1:107045587-107052303 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016377
protein coding gene Chr1:109253752-109259070 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0016321
protein coding gene Chr1:108302403-108308260 (-)
BALB/cJ MGP_BALBcJ_G0016318
protein coding gene Chr1:105764970-105797946 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0016776
protein coding gene Chr1:113395182-113409680 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014495
protein coding gene Chr1:99744826-99750620 (-)
CAST/EiJ MGP_CASTEiJ_G0015726
protein coding gene Chr1:107672510-107948255 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0016224
protein coding gene Chr1:104719290-104725545 (-)
FVB/NJ MGP_FVBNJ_G0016223
protein coding gene Chr1:103409817-103682867 (-)
LP/J MGP_LPJ_G0016296
protein coding gene Chr1:110443287-110449898 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016249
protein coding gene Chr1:121685785-121696600 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016815
protein coding gene Chr1:108378111-108384728 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0015301
protein coding gene Chr1:107041749-107047733 (-)
WSB/EiJ MGP_WSBEiJ_G0015790
protein coding gene Chr1:108484106-108487964 (-)



Homology
more
  • Human Ortholog
    SERPINB3, serpin family B member 3
  • Vertebrate Orthologs
    16
  • Human Ortholog
    SERPINB3, serpin family B member 3
    Orthology source: HGNC
  • Synonyms
    HsT1196, SCC, SCCA1, SCCA-1, SCCA-PD, SSCA1, T4-A
  • Links
    NCBI Gene ID: 6317
    neXtProt AC: NX_P29508
    UniProt: P29508

  • Chr Location
    18q21.33; chr18:63655197-63661963 (-)  GRCh38.p7

  • Human Ortholog
    SERPINB4, serpin family B member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LEUPIN, PI11, SCCA1, SCCA2, SCCA-2
  • Links
    NCBI Gene ID: 6318
    neXtProt AC: NX_P48594
    UniProt: P48594

  • Chr Location
    18q21.33; chr18:63637259-63644319 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced susceptibility to allergen-induced airway hyperresponsiveness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20248 NCBI Gene Model | MGI Sequence Detail 6717 C57BL/6J ±  kb
transcript NM_009126 RefSeq | MGI Sequence Detail 1629 C57BL/6  
polypeptide NP_033152 RefSeq | MGI Sequence Detail 387 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 6
    Genomic 1
    cDNA 5

    Microarray probesets 7
References
more
  • Summaries
    All 126
    Gene Ontology 3
    Phenotypes 104
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:265728 Lopes N, et al., Lymphotoxin alpha fine-tunes T cell clonal deletion by regulating thymic entry of antigen-presenting cells. Nat Commun. 2018 Mar 28;9(1):1262

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory