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Serpinb3a
Gene Detail
 Symbol
Name
ID
Serpinb3a
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
MGI:3573933
Synonyms Scca2, Serpinb4, Sqn5
Feature Type protein coding gene
Genetic Map
Chromosome 1
50.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:107045605-107052337 bp, - strand
From VEGA annotation of GRCm38

  6733 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:76659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 5 cattle; 1 dog; 3 chicken

Protein SuperFamily: serpin
Gene Tree: Serpinb3a

Human
homologs
Human Homolog SERPINB4, serpin peptidase inhibitor, clade B (ovalbumin), member 4
NCBI Gene ID 6318
neXtProt AC  NX_P48594
Human Synonyms  LEUPIN, PI11, SCCA1, SCCA2, SCCA-2
Human Chr (Location)  18q21.3; chr18:63637259-63644268 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit reduced susceptibility to allergen-induced airway hyperresponsiveness.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component extracellular region, extracellular vesicular exosome
Function enzyme binding, serine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(5) Genomic(1) cDNA(4)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000021000 (Evidence)
Ensembl Gene ModelENSMUSG00000044594 (Evidence)
Entrez Gene20248 (Evidence)
UniGene482944
DoTSDT.101376264
NIA Mouse Gene IndexU021665
Consensus CDS ProjectCCDS15214.1
International Mouse Knockout Project StatusSerpinb3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021000 VEGA Gene Model | MGI Sequence Detail 6733 C57BL/6J ±  kb
transcript OTTMUST00000049647 VEGA | MGI Sequence Detail 1645 Not Applicable 
polypeptide OTTMUSP00000023036 VEGA | MGI Sequence Detail 387 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(84 from dbSNP Build 137)    SNPs within 2kb including multiple locations(86)
Protein-related
information
ResourceIDDescription
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
References (Earliest) J:49294 Bartuski AJ, et al., A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases. Genomics. 1998 Dec 1;54(2):297-306
(Latest) J:189949 Sivaprasad U, et al., A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. J Allergy Clin Immunol. 2011 Jan;127(1):254-61, 261.e1-6
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory