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Serpinb3a
Gene Detail
Symbol

Name
ID
Serpinb3a
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
MGI:3573933
Synonyms
Scca2, Serpinb4, Sqn5
Feature Type
protein coding gene
Genetic Map
Chromosome 1
50.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:107045605-107052303 bp, - strand
From VEGA annotation of GRCm38

  6699 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:76659  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 5 cattle; 1 dog; 3 chicken; 1 western clawed frog

HCOP human homology predictions: SERPINB4
Protein SuperFamily: serpin
Gene Tree: Serpinb3a

Human
homologs
SERPINB4, serpin peptidase inhibitor, clade B (ovalbumin), member 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6318
neXtProt AC: NX_P48594

Human Synonyms: LEUPIN, PI11, SCCA1, SCCA2, SCCA-2

Human Chr (Location): 18q21.3; chr18:63637259-63644319 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(3) Transgenic(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit reduced susceptibility to allergen-induced airway hyperresponsiveness.
 
Interactions
Serpinb3a interacts with 82 markers (Mir23a, Mir23b, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component extracellular exosome, extracellular space, ...
Function enzyme binding, protease binding, ...
External Resources: FuncBase
Expression
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) Genomic(1) cDNA(4)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000021000 (Evidence)
Ensembl Gene Model ENSMUSG00000044594 (Evidence)
Entrez Gene 20248 (Evidence)
UniGene 482944
DoTS DT.101376264
NIA Mouse Gene Index U021665
Consensus CDS Project CCDS15214.1
International Mouse Phenotyping Consortium Status Serpinb3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021000 VEGA Gene Model | MGI Sequence Detail 6699 C57BL/6J ±  kb
transcript OTTMUST00000049647 VEGA | MGI Sequence Detail 1611 Not Applicable 
polypeptide OTTMUSP00000023036 VEGA | MGI Sequence Detail 387 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)    SNPs within 2kb including multiple locations(86)
Protein-related
information
ResourceIDDescription
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
References
(Earliest) J:49294 Bartuski AJ, et al., A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases. Genomics. 1998 Dec 1;54(2):297-306
(Latest) J:216188 Sivaprasad U, et al., SERPINB3/B4 Contributes to Early Inflammation and Barrier Dysfunction in an Experimental Murine Model of Atopic Dermatitis. J Invest Dermatol. 2015 Jan;135(1):160-9
All references(24)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory