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Crocc Gene Detail
Summary
  • Symbol
    Crocc
  • Name
    ciliary rootlet coiled-coil, rootletin
  • Feature Type
    protein coding gene
  • IDs
    MGI:3529431
    NCBI Gene: 230872
  • Gene Overview
    MyGene.info: CROCC
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141016637-141060550 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 73.31 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    575 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3529431
protein coding gene Chr4:141016637-141060616 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029036
protein coding gene Chr4:144007847-144058657 (-)
A/J MGP_AJ_G0028995
protein coding gene Chr4:137777381-137820867 (-)
AKR/J MGP_AKRJ_G0028947
protein coding gene Chr4:141747787-141791168 (-)
BALB/cJ MGP_BALBcJ_G0029019
protein coding gene Chr4:138465961-138510245 (-)
C3H/HeJ MGP_C3HHeJ_G0028733
protein coding gene Chr4:142131807-142176690 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029460
protein coding gene Chr4:149066140-149114347 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026731
protein coding gene Chr4:130691007-130735955 (-)
CAST/EiJ MGP_CASTEiJ_G0028165
protein coding gene Chr4:140382861-140426678 (-)
CBA/J MGP_CBAJ_G0028697
protein coding gene Chr4:153356399-153403328 (-)
DBA/2J MGP_DBA2J_G0028847
protein coding gene Chr4:138170336-138216535 (-)
FVB/NJ MGP_FVBNJ_G0028814
protein coding gene Chr4:137273792-137320218 (-)
LP/J MGP_LPJ_G0028946
protein coding gene Chr4:144041094-144089913 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028840
protein coding gene Chr4:157219201-157264919 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029498
protein coding gene Chr4:142272825-142318305 (-)
PWK/PhJ MGP_PWKPhJ_G0027886
protein coding gene Chr4:135054011-135099294 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027711
protein coding gene Chr4:138102184-138145645 (-)
WSB/EiJ MGP_WSBEiJ_G0028243
protein coding gene Chr4:142554911-142600684 (-)



Homology
more
  • Human Ortholog
    CROCC, ciliary rootlet coiled-coil, rootletin
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CROCC, ciliary rootlet coiled-coil, rootletin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ROLT, TAX1BP2
  • Links
    NCBI Gene ID: 9696
    neXtProt AC: NX_Q5TZA2
    UniProt: Q5TZA2

  • Chr Location
    1p36.13; chr1:16914082-16972979 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation show no apparent functional deficits in phototransduction and ciliary beating in sensory and motile cilia. However, photoreceptors degenerate over time, and lungs appear prone to pathological changes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040860 Ensembl Gene Model | MGI Sequence Detail 43914 C57BL/6J ±  kb
    transcript ENSMUST00000102491 Ensembl | MGI Sequence Detail 6582 Not Applicable  
    polypeptide ENSMUSP00000099549 Ensembl | MGI Sequence Detail 2009 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 49

      Microarray probesets 2
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:80161 Yang J, et al., Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. J Cell Biol. 2002 Nov 11;159(3):431-40
    • Latest
      J:232855 Yadav SP, et al., Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis. Development. 2016 May 1;143(9):1491-501

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory