Rsc1a1
Gene Detail

Symbol Name ID

Rsc1a1 regulatory solute carrier protein, family 1, member 1 MGI:3526447

Synonyms

mRS1, OTTMUSG00000010365, RS1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

74.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:141683851-141685599 bp, - strand From VEGA annotation of GRCm38   1749 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:130554  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque

Gene Tree: Rsc1a1

Human homologs

Human Homolog		RSC1A1, regulatory solute carrier protein, family 1, member 1
NCBI Gene ID		6248
neXtProt AC		NX_Q92681
Human Synonyms		RS1
Human Chr (Location)		1p36.1; chr1:15986364-15988217 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous null mice develop obesity and exhibit increased serum cholesterol and leptin levels and increased absorption of D-glucose in the small intestine.

 
Human Diseases Modeled Using Mouse Rsc1a1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	intestinal absorption, negative regulation of transport, ...
Component	brush border, cell junction, ...
Function	protein binding

External Resources: FuncBase

Expression

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(4) cDNA(4)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000010365 (Evidence)
Ensembl Gene Model	ENSMUSG00000040715 (Evidence)
Entrez Gene	69994 (Evidence)
DoTS	DT.50316278
Consensus CDS Project	CCDS18879.1
International Mouse Knockout Project Status	Rsc1a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010365	VEGA Gene Model | MGI Sequence Detail	1749	C57BL/6J
transcript	OTTMUST00000024154	VEGA | MGI Sequence Detail	1749	Not Applicable
polypeptide	OTTMUSP00000011109	VEGA | MGI Sequence Detail	582	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Protein-related information

Resource	ID	Description
InterPro	IPR015940	Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
Protein Ontology	PR:000014321	regulatory solute carrier protein family 1 member 1

References

(Earliest) J:10021 Lai E, et al., Physical maps of the mouse and human immunoglobulin-like loci. Adv Immunol. 1989;46:1-59
(Latest) J:95148 Osswald C, et al., Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol Cell Biol. 2005 Jan;25(1):78-87
All references(17)

Other accession IDs

MGI:3707227