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Rsc1a1 Gene Detail
Summary
  • Symbol
    Rsc1a1
  • Name
    regulatory solute carrier protein, family 1, member 1
  • Synonyms
    mRS1, OTTMUSG00000010365, RS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3526447
    NCBI Gene: 69994
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:141410874-141413027 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 74.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3526447
 protein coding gene Chr4:141410874-141413027 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029055
 protein coding gene Chr4:144773950-144775698 (-)
A/J MGP_AJ_G0029015
 protein coding gene Chr4:138460752-138462500 (-)
AKR/J MGP_AKRJ_G0028967
 protein coding gene Chr4:142486621-142488369 (-)
BALB/cJ MGP_BALBcJ_G0029039
 protein coding gene Chr4:139158654-139160402 (-)
C3H/HeJ MGP_C3HHeJ_G0028753
 protein coding gene Chr4:142849644-142851392 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029480
 protein coding gene Chr4:149813723-149815471 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026751
 protein coding gene Chr4:131375551-131377305 (-)
CAST/EiJ MGP_CASTEiJ_G0028185
 protein coding gene Chr4:141119232-141120980 (-)
CBA/J MGP_CBAJ_G0028717
 protein coding gene Chr4:154228162-154236345 (-)
DBA/2J MGP_DBA2J_G0028867
 protein coding gene Chr4:138857580-138859328 (-)
FVB/NJ MGP_FVBNJ_G0028834
 protein coding gene Chr4:137978148-137979896 (-)
LP/J MGP_LPJ_G0028966
 protein coding gene Chr4:144791894-144793642 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028860
 protein coding gene Chr4:157965668-157967416 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029518
 protein coding gene Chr4:143002451-143004199 (-)
PWK/PhJ MGP_PWKPhJ_G0027906
 protein coding gene Chr4:135751408-135753156 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027730
 protein coding gene Chr4:138813353-138815101 (-)
WSB/EiJ MGP_WSBEiJ_G0028263
 protein coding gene Chr4:143273926-143275674 (-)



Homology
more
  • Human Ortholog
    RSC1A1, regulator of solute carriers 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RSC1A1, regulator of solute carriers 1
  • Synonyms
    RS1
  • Links
    NCBI Gene ID: 6248
    UniProt: Q92681

  • Chr Location
    1p36.21; chr1:15659713-15662033 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rsc1a1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop obesity and exhibit increased serum cholesterol and leptin levels and increased absorption of D-glucose in the small intestine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69994 NCBI Gene Model | MGI Sequence Detail 2154 C57BL/6J ±  kb
transcript NM_023544 RefSeq | MGI Sequence Detail 2154 C57BL/6  
polypeptide Q9ER99 UniProt | EBI | MGI Sequence Detail 582 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 2
Other
Accession IDs
less
MGI:3707227
References
more
  • Summaries
    All 24
    Diseases 1
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:10021 Lai E, et al., Physical maps of the mouse and human immunoglobulin-like loci. Adv Immunol. 1989;46:1-59
  • Latest
    J:266504 Sebastiani A, et al., RS1 (Rsc1A1) deficiency limits cerebral SGLT1 expression and delays brain damage after experimental traumatic brain injury. J Neurochem. 2018 Oct;147(2):190-203
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory