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Rsc1a1
Gene Detail
Symbol

Name
ID
Rsc1a1
regulatory solute carrier protein, family 1, member 1
MGI:3526447
Synonyms
mRS1, OTTMUSG00000010365, RS1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
74.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:141683851-141685599 bp, - strand
From VEGA annotation of GRCm38

  1749 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:130554  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque

Gene Tree: Rsc1a1

Human
homologs
Human Homolog RSC1A1, regulatory solute carrier protein, family 1, member 1
NCBI Gene ID 6248
neXtProt AC  NX_Q92681
Human Synonyms  RS1
Human Chr (Location)  1p36.1; chr1:15659869-15661722 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice develop obesity and exhibit increased serum cholesterol and leptin levels and increased absorption of D-glucose in the small intestine.
 
Human Diseases Modeled Using Mouse Rsc1a1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Rsc1a1 interacts with 82 markers (Mir1a-1, Mir1a-2, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process intestinal absorption, negative regulation of transport
Component brush border, cell junction, ...
Function protein binding
External Resources: FuncBase
Expression
cDNA source data(3)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000010365 (Evidence)
Ensembl Gene ModelENSMUSG00000040715 (Evidence)
Entrez Gene69994 (Evidence)
DoTSDT.50316278
Consensus CDS ProjectCCDS18879.1
International Mouse Knockout Project StatusRsc1a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010365 VEGA Gene Model | MGI Sequence Detail 1749 C57BL/6J ±  kb
transcript OTTMUST00000024154 VEGA | MGI Sequence Detail 1749 Not Applicable 
polypeptide OTTMUSP00000011109 VEGA | MGI Sequence Detail 582 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000014321 regulatory solute carrier protein family 1 member 1
References
(Earliest) J:10021 Lai E, et al., Physical maps of the mouse and human immunoglobulin-like loci. Adv Immunol. 1989;46:1-59
(Latest) J:95148 Osswald C, et al., Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity. Mol Cell Biol. 2005 Jan;25(1):78-87
All references(15)
Disease annotation references (1)
Other
accession IDs
MGI:3707227

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory