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Zfp36l3 Gene Detail
Summary
  • Symbol
    Zfp36l3
  • Name
    zinc finger protein 36, C3H type-like 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3525151
    NCBI Gene: 333473
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:52776015-52778361 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 30.06 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3525151
 protein coding gene ChrX:52774653-52778361 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035731
 protein coding gene ChrX:49051420-49053766 (-)
A/J MGP_AJ_G0035713
 protein coding gene ChrX:48941892-48944238 (-)
AKR/J MGP_AKRJ_G0035634
 protein coding gene ChrX:50312898-50315244 (-)
BALB/cJ MGP_BALBcJ_G0035700
 protein coding gene ChrX:48415812-48418158 (-)
C3H/HeJ MGP_C3HHeJ_G0035403
 protein coding gene ChrX:49326672-49329018 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036229
 protein coding gene ChrX:50230727-50233073 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033081
 protein coding gene ChrX:46328803-46331085 (-)
CAST/EiJ MGP_CASTEiJ_G0034696
 protein coding gene ChrX:36616353-36618699 (-)
CBA/J MGP_CBAJ_G0035377
 protein coding gene ChrX:51623206-51625552 (-)
DBA/2J MGP_DBA2J_G0035532
 protein coding gene ChrX:48671714-48674060 (-)
FVB/NJ MGP_FVBNJ_G0035481
 protein coding gene ChrX:48296197-48298543 (-)
LP/J MGP_LPJ_G0035620
 protein coding gene ChrX:49433242-49435588 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035520
 protein coding gene ChrX:53159907-53162253 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036247
 protein coding gene ChrX:48945482-48947828 (-)
PWK/PhJ MGP_PWKPhJ_G0034394
 protein coding gene ChrX:36150538-36152884 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034237
 protein coding gene ChrX:37431509-37433822 (-)
WSB/EiJ MGP_WSBEiJ_G0034839
 protein coding gene ChrX:48509136-48511482 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mice show decreased neonatal survival rates but those that survive are viable and fertile. Iron and zinc levels are decreased in fetuses. Paternal imprinting occurs in heterozygous females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    32
  • cDNA Data
    9
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059334 Ensembl Gene Model | MGI Sequence Detail 2347 C57BL/6J ±  kb
transcript ENSMUST00000071711 Ensembl | MGI Sequence Detail 2347 Not Applicable  
polypeptide ENSMUSP00000071630 Ensembl | MGI Sequence Detail 725 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR045877 RNA-binding protein ZFP36-like
    IPR011004 Trimeric LpxA-like superfamily
    IPR000571 Zinc finger, CCCH-type
    IPR036855 Zinc finger, CCCH-type superfamily
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 17
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 2
  • Earliest
    J:100670 Blackshear PJ, et al., Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. Biol Reprod. 2005 Aug;73(2):297-307
  • Latest
    J:230794 Stumpo DJ, et al., Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. Development. 2016 Apr 15;143(8):1424-33
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory