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Ppp1r13l Gene Detail
Summary
  • Symbol
    Ppp1r13l
  • Name
    protein phosphatase 1, regulatory (inhibitor) subunit 13 like
  • Synonyms
    IASPP, NFkB interacting protein 1, wa3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3525053
    NCBI Gene: 333654
  • Gene Overview
    MyGene.info: PPP1R13L
Location & Maps
more
  • Sequence Map
    Chr7:19359749-19378533 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18785 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.62 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PPP1R13L, protein phosphatase 1 regulatory subunit 13 like
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PPP1R13L, protein phosphatase 1 regulatory subunit 13 like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IASPP, NKIP1, RAI, RAI4
  • Links
    NCBI Gene ID: 10848
    neXtProt AC: NX_Q8WUF5

  • Chr Location
    19q13.32; chr19:45379634-45406349 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 5 alleles in 5 genetic backgrounds
    8 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    4
  • Spontaneous
    3
  • Targeted
    2
  • Incidental Mutations
Homozygotes for spontaneous mutations in this gene exhibit cardiovascular defects leading to cardiomyopathy, open eyelids at birth, and coat abnormalities. One allele also shows postnatal lethality dependent on strain background and decreased weight, while another shows impaired fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase ppp1r13l
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029180 VEGA Gene Model | MGI Sequence Detail 18785 C57BL/6J ±  kb
transcript OTTMUST00000072367 VEGA | MGI Sequence Detail 3130 Not Applicable  
polypeptide OTTMUSP00000037232 VEGA | MGI Sequence Detail 824 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    96 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 28
    cDNA 26
    Primer pair 1
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1890874, MGI:2142182
References
more
  • Summaries
    All 34
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
  • Latest
    J:220162 Notari M, et al., iASPP, a previously unidentified regulator of desmosomes, prevents arrhythmogenic right ventricular cardiomyopathy (ARVC)-induced sudden death. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E973-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory