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Ppp1r13l
Gene Detail
 Symbol
Name
ID
Ppp1r13l
protein phosphatase 1, regulatory (inhibitor) subunit 13 like
MGI:3525053
Synonyms IASPP, NFkB interacting protein 1, wa3
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:19359749-19378533 bp, + strand
From VEGA annotation of GRCm38

  18785 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84635  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Ppp1r13l

Human
homologs
Human Homolog PPP1R13L, protein phosphatase 1, regulatory subunit 13 like
NCBI Gene ID 10848
neXtProt AC  NX_Q8WUF5
Human Synonyms  IASPP, NKIP1, RAI, RAI4
Human Chr (Location)  19q13.32; chr19:45379634-45406480 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(4) Spontaneous(3) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for spontaneous mutations in this gene exhibit cardiovascular defects leading to cardiomyopathy, open eyelids at birth, and coat abnormalities. One allele also shows postnatal lethality dependent on strain background and decreased weight, while another shows impaired fertility.
 
Phenotype Images(7)
Interactions
Ppp1r13l interacts with 87 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process apoptotic process, cardiac muscle contraction, ...
Component cell junction, cytoplasm, ...
Function identical protein binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (22)    Tissues (4)    Images (19)
Theiler Stages: 23
Assay TypeResults
RNA in situ 22
cDNA source data(26)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(26) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000029180 (Evidence)
Ensembl Gene ModelENSMUSG00000040734 (Evidence)
Entrez Gene333654 (Evidence)
UniGene333640
DFCITC1585417, TC1617961, TC1718350
DoTSDT.101289130, DT.94181212, DT.97358659
NIA Mouse Gene IndexU007763
Consensus CDS ProjectCCDS20899.1
International Mouse Knockout Project StatusPpp1r13l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029180 VEGA Gene Model | MGI Sequence Detail 18785 C57BL/6J ±  kb
transcript OTTMUST00000072367 VEGA | MGI Sequence Detail 3130 Not Applicable 
polypeptide OTTMUSP00000037232 VEGA | MGI Sequence Detail 824 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(10) UniProt(5)
Polymorphisms SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000013111 RelA-associated inhibitor
References (Earliest) J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
(Latest) J:190557 Toonen J, et al., Waved with open eyelids 2 (woe2) is a novel spontaneous mouse mutation in the protein phosphatase 1, regulatory (inhibitor) subunit 13 like (Ppp1r13l) gene. BMC Genet. 2012;13:76
All references(38)
Other
accession IDs
MGI:1890874, MGI:2142182

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory