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Csta1 Gene Detail
Summary
  • Symbol
    Csta1
  • Name
    cystatin A1
  • Synonyms
    Csta
  • Feature Type
    protein coding gene
  • IDs
    MGI:3524930
    NCBI Gene: 209294
  • Gene Overview
    MyGene.info: CSTA
Location & Maps
more
  • Sequence Map
    Chr16:36119946-36131241 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11296 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 25.43 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CSTA, cystatin A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CSTA, cystatin A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AREI, PSS4, STF1, STFA
  • Links
    NCBI Gene ID: 1475
    neXtProt AC: NX_P01040

  • Chr Location
    3q21; chr3:122325164-122341969 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CSTA associations

Human Disease Mouse Models
       Peeling Skin Syndrome 4; PSS4   OMIM: 607936
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    2
  • Not Applicable
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Csta1
  • Incidental Mutations
    APF , CvDC
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Other Mouse Links
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026729 VEGA Gene Model | MGI Sequence Detail 11296 C57BL/6J ±  kb
transcript OTTMUST00000066119 VEGA | MGI Sequence Detail 2783 Not Applicable  
polypeptide OTTMUSP00000033075 VEGA | MGI Sequence Detail 97 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    62 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR000010 Cystatin domain
    IPR001713 Proteinase inhibitor I25A, stefin A
    IPR018073 Proteinase inhibitor I25, cystatin, conserved site
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 3
References
more
  • Summaries
    All 25
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory