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Csta1
Gene Detail
 Symbol
Name
ID
Csta1
cystatin A1
MGI:3524930
Synonyms Csta
Feature Type protein coding gene
Genetic Map
Chromosome 16
25.43 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr16:36119946-36131241 bp, - strand
From VEGA annotation of GRCm38

  11296 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3819  Vertebrate Homology Class
1 human; 3 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Csta1

Human
homologs
Human Homolog CSTA, cystatin A (stefin A)
NCBI Gene ID 1475
neXtProt AC  NX_P01040
Human Synonyms  AREI, STF1, STFA
Human Chr (Location)  3q21; chr3:122325164-122341969 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CSTA
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Not Applicable(1) Targeted(2)
Genomic Mutations involving Csta1 (1)
Incidental mutations (data from APF )
Interactions
Csta1 interacts with 260 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process negative regulation of endopeptidase activity, negative regulation of peptidase activity
Component cornified envelope, cytoplasm, ...
Function cysteine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity, ...
External Resources: FuncBase
Expression
cDNA source data(12)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026729 (Evidence)
Ensembl Gene ModelENSMUSG00000034362 (Evidence)
Entrez Gene209294 (Evidence)
UniGene300592
DFCITC1585337
DoTSDT.490576
NIA Mouse Gene IndexU037017
Consensus CDS ProjectCCDS37327.1
International Mouse Knockout Project StatusCsta1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026729 VEGA Gene Model | MGI Sequence Detail 11296 C57BL/6J ±  kb
transcript OTTMUST00000066119 VEGA | MGI Sequence Detail 2783 Not Applicable 
polypeptide OTTMUSP00000033075 VEGA | MGI Sequence Detail 97 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(3) UniProt(3)
Polymorphisms SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001713 Proteinase inhibitor I25A, stefin A
InterPro IPR000010 Proteinase inhibitor I25, cystatin
InterPro IPR018073 Proteinase inhibitor I25, cystatin, conserved site
Protein Ontology PR:000005973 cystatin-A
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory