About   Help   FAQ
Trpa1 Gene Detail
Summary
  • Symbol
    Trpa1
  • Name
    transient receptor potential cation channel, subfamily A, member 1
  • Synonyms
    ANKTM1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3522699
    NCBI Gene: 277328
Location & Maps
more
  • Sequence Map
    Chr1:14872648-14918862 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46215 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 4.50 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TRPA1, transient receptor potential cation channel subfamily A member 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TRPA1, transient receptor potential cation channel subfamily A member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANKTM1, FEPS
  • Links
    NCBI Gene ID: 8989
    neXtProt AC: NX_O75762

  • Chr Location
    8q13; chr8:72021251-72090009 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TRPA1 associations

Human Disease Mouse Models
       Episodic Pain Syndrome, Familial, 1; FEPS1   OMIM: 615040
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 5 alleles in 4 genetic backgrounds
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in altered nociception and neuron responses to isothiocyanate or thiosulfinate compounds like those found in mustard oil and garlic.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049207 VEGA Gene Model | MGI Sequence Detail 46215 C57BL/6J ±  kb
transcript OTTMUST00000125545 VEGA | MGI Sequence Detail 4263 Not Applicable  
polypeptide OTTMUSP00000068034 VEGA | MGI Sequence Detail 1125 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    540 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000000699 transient receptor potential cation channel TRPA1
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
    IPR005821 Ion transport domain
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 114
    Developmental Gene Expression 13
    Gene Ontology 15
    Phenotypes 59
  • Earliest
    J:96171 Story GM, et al., ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29
  • Latest
    J:229909 Akiyama T, et al., Involvement of TRPV4 in Serotonin-Evoked Scratching. J Invest Dermatol. 2016 Jan;136(1):154-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory