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Trpa1
Gene Detail
 Symbol
Name
ID
Trpa1
transient receptor potential cation channel, subfamily A, member 1
MGI:3522699
Synonyms ANKTM1
Feature Type protein coding gene
Genetic Map
Chromosome 1
4.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:14872648-14918862 bp, - strand
From NCBI annotation of GRCm38

  46215 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: transient receptor potential cation channel, subfamily A
Gene Tree: Trpa1

Human
homologs
Human Homolog TRPA1, transient receptor potential cation channel, subfamily A, member 1
NCBI Gene ID 8989
neXtProt AC  NX_O75762
Human Synonyms  ANKTM1, FEPS
Human Chr (Location)  8q13; chr8:72021251-72075584 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TRPA1
Alleles
and
phenotypes
All alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene result in altered nociception and neuron responses to isothiocyanate or thiosulfinate compounds like those found in mustard oil and garlic.
 
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process calcium ion transmembrane transport, calcium ion transport, ...
Component integral component of membrane, membrane, ...
Function calcium channel activity, channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (60)    Tissues (53)    Images (6)
Theiler Stages: 23, 25, 26, 28
Assay TypeResults
RNA in situ 53
RT-PCR 7
cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(1)
Other database
links
Ensembl Gene ModelENSMUSG00000032769 (Evidence)
Entrez Gene277328 (Evidence)
UniGene186329
DFCITC1587947
DoTSDT.94182330
NIA Mouse Gene IndexU021135
Consensus CDS ProjectCCDS35516.1
International Mouse Knockout Project StatusTrpa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 277328 NCBI Gene Model | MGI Sequence Detail 46215 C57BL/6J ±  kb
transcript NM_177781 RefSeq | MGI Sequence Detail 4263 C57BL/6 
polypeptide Q8BLA8 UniProt | EBI | MGI Sequence Detail 1125 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(6) UniProt(2)
Polymorphisms SNPs within 2kb(536 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000000699 transient receptor potential cation channel TRPA1
Graphical View of Protein Domain Structure
References (Earliest) J:96171 Story GM, et al., ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29
(Latest) J:210458 de Oliveira C, et al., Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents. J Neurosci. 2014 Mar 26;34(13):4445-52
All references(87)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory