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Trpa1
Gene Detail
Symbol

Name
ID
Trpa1
transient receptor potential cation channel, subfamily A, member 1
MGI:3522699
Synonyms
ANKTM1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
4.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr1:14872648-14918862 bp, - strand
From VEGA annotation of GRCm38

  46215 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7189  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TRPA1
Protein SuperFamily: transient receptor potential cation channel, subfamily A
Gene Tree: Trpa1

Human
homologs
TRPA1, transient receptor potential cation channel, subfamily A, member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8989
neXtProt AC: NX_O75762

Human Synonyms: ANKTM1, FEPS

Human Chr (Location): 8q13; chr8:72021251-72090009 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TRPA1

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mutations in this gene result in altered nociception and neuron responses to isothiocyanate or thiosulfinate compounds like those found in mustard oil and garlic.
 
Interactions
Trpa1 interacts with 221 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process calcium ion transmembrane import into cytosol, calcium ion transmembrane transport, ...
Component apical plasma membrane, axon, ...
Function calcium channel activity, channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (60)    Tissues (54)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 53
RT-PCR 7
cDNA source data(7)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase trpa1 ; ZFIN trpa1a, trpa1b    NEW 
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000049207 (Evidence)
Ensembl Gene Model ENSMUSG00000032769 (Evidence)
Entrez Gene 277328 (Evidence)
UniGene 186329
DFCI TC1587947
DoTS DT.94182330
NIA Mouse Gene Index U021135
Consensus CDS Project CCDS35516.1
International Mouse Phenotyping Consortium Status Trpa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049207 VEGA Gene Model | MGI Sequence Detail 46215 C57BL/6J ±  kb
transcript OTTMUST00000125545 VEGA | MGI Sequence Detail 4263 Not Applicable 
polypeptide OTTMUSP00000068034 VEGA | MGI Sequence Detail 1125 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(536 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR030288 Transient receptor potential ankyrin 1 channel
Protein Ontology PR:000000699 transient receptor potential cation channel TRPA1
References
(Earliest) J:96171 Story GM, et al., ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29
(Latest) J:221586 Lou S, et al., Incoherent feed-forward regulatory loops control segregation of C-mechanoreceptors, nociceptors, and pruriceptors. J Neurosci. 2015 Apr 1;35(13):5317-29
All references(103)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory