Kcnk9
Gene Detail

Symbol Name ID

Kcnk9 potassium channel, subfamily K, member 9 MGI:3521816

Synonyms

Task3

Feature Type

protein coding gene

Genetic Map

Chromosome 15

33.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr15:72512119-72546279 bp, - strand From NCBI annotation of GRCm38   34161 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56758  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium channel, subfamily K type
Gene Tree: Kcnk9

Human homologs

Human Homolog		KCNK9, potassium channel, subfamily K, member 9
NCBI Gene ID		51305
neXtProt AC		NX_Q9NPC2
Human Synonyms		K2p9.1, KT3.2, TASK3, TASK-3
Human Chr (Location)		8q24.3; chr8:140624804-140715299 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KCNK9

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for a null allele exhibit decreased pH sensitive action potential in serotonergic neurons.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	ion transport, potassium ion transmembrane transport, ...
Component	integral to membrane, membrane, ...
Function	potassium channel activity, protein heterodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (21)    Tissues (11)   
Theiler Stages: 2, 3, 4, 5, 28

Assay Type	Results
Immunohistochemistry	3
RT-PCR	18

cDNA source data(2)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(4) cDNA(2) Primer pair(2)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000036760 (Evidence)
Entrez Gene	223604 (Evidence)
UniGene	386856
DoTS	DT.110789637
NIA Mouse Gene Index	U090668
Consensus CDS Project	CCDS27515.1
International Mouse Knockout Project Status	Kcnk9

Sequences

Length	Strain/Species
genomic	223604	NCBI Gene Model | MGI Sequence Detail	34161	C57BL/6J
transcript	NM_001033876	RefSeq | MGI Sequence Detail	1209	NMRI
polypeptide	Q3LS21	UniProt | EBI | MGI Sequence Detail	402	Not Applicable

All sequences(12) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(121 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013099	Ion transport 2
InterPro	IPR003280	Two pore domain potassium channel
InterPro	IPR005407	Two pore domain potassium channel, TASK-3
InterPro	IPR003092	Two pore domain potassium channel, TASK family
InterPro	IPR022306	Two pore domain potassium channel, TASK/TWIK
Protein Ontology	PR:000002079	potassium channel subfamily K member 9

Graphical View of Protein Domain Structure

References

(Earliest) J:124944 Brickley SG, et al., TASK-3 two-pore domain potassium channels enable sustained high-frequency firing in cerebellar granule neurons. J Neurosci. 2007 Aug 29;27(35):9329-40
(Latest) J:191435 Penton D, et al., Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension. Endocrinology. 2012 Oct;153(10):4740-8
All references(41)