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Kcnk9 Gene Detail
Summary
  • Symbol
    Kcnk9
  • Name
    potassium channel, subfamily K, member 9
  • Synonyms
    Task3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3521816
    NCBI Gene: 223604
  • Gene Overview
    MyGene.info: KCNK9
Location & Maps
more
  • Sequence Map
    Chr15:72512119-72546279 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34161 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    KCNK9, potassium two pore domain channel subfamily K member 9
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNK9, potassium two pore domain channel subfamily K member 9
    Orthology source: HGNC, HomoloGene
  • Synonyms
    K2p9.1, KT3.2, TASK3, TASK-3
  • Links
    NCBI Gene ID: 51305
    neXtProt AC: NX_Q9NPC2

  • Chr Location
    8q24.3; chr8:139600838-139703068 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KCNK9 associations

Human Disease Mouse Models
       Birk-Barel Mental Retardation Dysmorphism Syndrome   OMIM: 612292
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 4 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    3
  • Radiation induced
    2
  • Targeted
    10
  • Genomic Mutations
    5 involving Kcnk9
  • Incidental Mutations
Mice homozygous for a null allele exhibit decreased pH sensitive action potential in serotonergic neurons.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036760 Ensembl Gene Model | MGI Sequence Detail 34161 C57BL/6J ±  kb
transcript ENSMUST00000044624 Ensembl | MGI Sequence Detail 1209 Not Applicable  
polypeptide ENSMUSP00000038729 Ensembl | MGI Sequence Detail 402 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    158 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000002079 potassium channel subfamily K member 9
  • InterPro Domains
    IPR013099 Potassium channel domain
    IPR005407 Potassium channel subfamily K member 9
    IPR003280 Two pore domain potassium channel
    IPR003092 Two pore domain potassium channel, TASK family
Molecular
Reagents
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  • All nucleic 4
    cDNA 2
    Primer pair 2

    Microarray probesets 1
References
more
  • Summaries
    All 45
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 6
    Phenotypes 42
  • Earliest
    J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-15;
  • Latest
    J:220586 Bando Y, et al., Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex. Cereb Cortex. 2014 Apr;24(4):1017-29

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory