Nt5dc3 MGI Mouse Gene Detail - MGI:3513266 - 5'-nucleotidase domain containing 3

Symbol

Nt5dc3
Name

5'-nucleotidase domain containing 3
Synonyms

C630002B14Rik, Gnn

Feature Type

protein coding gene
IDs

MGI:3513266
NCBI Gene: 103466
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:86779005-86838389 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 43.11 cM
Mapping Data

4 experiments

SNPs within 2kb

285 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3513266	protein coding gene	Chr10:86778992-86838389 (.)
129S1/SvImJ	MGP_129S1SvImJ_G0017615	protein coding gene	Chr10:87764563-87819050 (+)
A/J	MGP_AJ_G0017594	protein coding gene	Chr10:84860885-84913564 (+)
AKR/J	MGP_AKRJ_G0017552	protein coding gene	Chr10:87242728-87301861 (+)
BALB/cJ	MGP_BALBcJ_G0017557	protein coding gene	Chr10:85123273-85176330 (+)
C3H/HeJ	MGP_C3HHeJ_G0017380	protein coding gene	Chr10:87243935-87297345 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018014	protein coding gene	Chr10:90734257-90793302 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015696	protein coding gene	Chr10:80660630-80715663 (+)
CAST/EiJ	MGP_CASTEiJ_G0016945	protein coding gene	Chr10:87134629-87192218 (+)
CBA/J	MGP_CBAJ_G0017349	protein coding gene	Chr10:94502414-94563326 (+)
DBA/2J	MGP_DBA2J_G0017455	protein coding gene	Chr10:83963139-84017473 (+)
FVB/NJ	MGP_FVBNJ_G0017447	protein coding gene	Chr10:83227397-83288938 (+)
LP/J	MGP_LPJ_G0017529	protein coding gene	Chr10:88458684-88514902 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017478	protein coding gene	Chr10:96075536-96129759 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018051	protein coding gene	Chr10:87093013-87145910 (+)
PWK/PhJ	MGP_PWKPhJ_G0016726	protein coding gene	Chr10:83970468-84031225 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016514	protein coding gene	Chr10:85815702-85873618 (+)
WSB/EiJ	MGP_WSBEiJ_G0017004	protein coding gene	Chr10:87050687-87112221 (+)

Human Ortholog

NT5DC3, 5'-nucleotidase domain containing 3

Vertebrate Orthologs

10

Human Ortholog

NT5DC3, 5'-nucleotidase domain containing 3
Orthology source: HomoloGene, HGNC
Synonyms

TU12B1TY, TU12B1-TY
Links

HGNC:30826

NCBI Gene ID: 51559

neXtProt AC: NX_Q86UY8

UniProt: Q86UY8
Chr Location

12q23.3; chr12:103746315-103841238 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 9571
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NT5DC3
Protein SuperFamily

cytosolic purine 5'-nucleotidase
Gene Tree

Nt5dc3

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Phenotype Summary

10 phenotype references

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

5
Genomic Mutations

1 involving Nt5dc3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available

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All GO Annotations

7
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

15
Tissues

15
cDNA Data

35
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nt5dc3

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Nt5dc3 interacts with 334 markers (Mir7-1, Mir10a, Mir15a, ...) View All

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All Sequences

42
RefSeq

4
UniProt

3
CCDS

CCDS36020.1
UniGene

200446

Ensembl

ENSMUSG00000054027 (Evidence)
NCBI Gene

103466

			Length	Strain/Species	Flank
genomic	ENSMUSG00000054027	Ensembl Gene Model \| MGI Sequence Detail	59385	C57BL/6J	± kb
transcript	ENSMUST00000099396	Ensembl \| MGI Sequence Detail	5952	Not Applicable
polypeptide	ENSMUSP00000096994	Ensembl \| MGI Sequence Detail	546	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000031877 5'-nucleotidase domain-containing protein 3

(term hierarchy)
EC

3.1.3.-
InterPro Domains

IPR036412 HAD-like superfamily

IPR023214 HAD superfamily

IPR008380 HAD-superfamily hydrolase, subfamily IG, 5'-nucleotidase

IPR016695 Purine 5'-nucleotidase

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All nucleic 35

cDNA 35

Microarray probesets 4

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MGI:2143753, MGI:2143852

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 10
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52

TSS for Nt5dc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr95009	Chr10:86779000-86779009 (+)	0 bp
Tssr95010	Chr10:86779019-86779044 (+)	27 bp
Tssr95011	Chr10:86779046-86779068 (+)	52 bp
Tssr95012	Chr10:86779075-86779095 (+)	80 bp
Tssr95013	Chr10:86779097-86779104 (+)	96 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/08/2019 MGI 6.13