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Tmprss11e
Gene Detail
Symbol

Name
ID
Tmprss11e
transmembrane protease, serine 11e
MGI:3513175
Synonyms
DESC1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
43.56 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:86705186-86745815 bp, - strand
From VEGA annotation of GRCm38

  40630 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8543  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog

Protein SuperFamily: transmembrane serine protease, TMPRSS11A type
Gene Tree: Tmprss11e

Human
homologs
Human Homolog TMPRSS11E, transmembrane protease, serine 11E
NCBI Gene ID 28983
neXtProt AC  NX_Q9UL52
Human Synonyms  DESC1, TMPRSS11E2
Human Chr (Location)  4q13.2; chr4:68447449-68497604 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tmprss11e interacts with 322 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cognition, proteolysis
Component extracellular region, integral component of membrane, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (4)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 4
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000035105 (Evidence)
Ensembl Gene ModelENSMUSG00000054537 (Evidence)
Entrez Gene243084 (Evidence)
UniGene130801
DFCITC1589499
DoTSDT.94284080
NIA Mouse Gene IndexU026354
EC3.4.21.-
Consensus CDS ProjectCCDS51533.1
International Mouse Knockout Project StatusTmprss11e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035105 VEGA Gene Model | MGI Sequence Detail 40630 C57BL/6J ±  kb
transcript OTTMUST00000089305 VEGA | MGI Sequence Detail 3416 Not Applicable 
polypeptide OTTMUSP00000048794 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(330 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR017329 Peptidase S1A, HAT/DESC1
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR000082 SEA domain
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000016451 transmembrane protease serine 11E
References
(Earliest) J:94483 Hobson JP, et al., Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. J Biol Chem. 2004 Nov 5;279(45):46981-94
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory