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A4galt Gene Detail
Summary
  • Symbol
    A4galt
  • Name
    alpha 1,4-galactosyltransferase
  • Synonyms
    Gb3 synthase
  • Feature Type
    protein coding gene
  • IDs
    MGI:3512453
    NCBI Gene: 239559
  • Gene Overview
    MyGene.info: A4GALT
Location & Maps
more
  • Sequence Map
    Chr15:83226726-83251774 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25049 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 39.40 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    A4GALT, alpha 1,4-galactosyltransferase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    A4GALT, alpha 1,4-galactosyltransferase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A14GALT, A4GALT1, Gb3S, P1, P1PK, P(k), PK
  • Links
    NCBI Gene ID: 53947
    neXtProt AC: NX_Q9NPC4

  • Chr Location
    22q13.2; chr22:42692117-42721301 (-)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    20 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    121
  • Chemically induced (other)
    1
  • Gene trapped
    112
  • Radiation induced
    2
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    3 involving A4galt
  • Incidental Mutations
Homozygous null mice display reduced sensitivity to verotoxin but do not display any gross morphological abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047878 Ensembl Gene Model | MGI Sequence Detail 25049 C57BL/6J ±  kb
transcript ENSMUST00000049530 Ensembl | MGI Sequence Detail 2088 Not Applicable  
polypeptide ENSMUSP00000057999 Ensembl | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    81 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Diseases 3
    Gene Ontology 6
    Phenotypes 32
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:213489 Porubsky S, et al., Direct acute tubular damage contributes to Shigatoxin-mediated kidney failure. J Pathol. 2014 Sep;234(1):120-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory