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Foxi3 Gene Detail
Summary
  • Symbol
    Foxi3
  • Name
    forkhead box I3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3511278
    NCBI Gene: 232077
Location & Maps
more
  • Sequence Map
    Chr6:70956531-70961063 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4533 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.14 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FOXI3, forkhead box I3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FOXI3, forkhead box I3
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 344167
    neXtProt AC: NX_A8MTJ6

  • Chr Location
    2p11.2; chr2:88448207-88452535 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice start dying after E9.5. Those born die neonatally, lack a mouth and whiskers, and show branchial arch-derived skeletal defects, including a reduced mandible, total absence of inner, middle and external ear structures, and increased cranial neural crest cell apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034294 VEGA Gene Model | MGI Sequence Detail 4533 C57BL/6J ±  kb
transcript OTTMUST00000087202 VEGA | MGI Sequence Detail 1278 Not Applicable  
polypeptide OTTMUSP00000047315 VEGA | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    18 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001766 Fork head domain
    IPR018122 Fork head domain conserved site1
    IPR030456 Fork head domain conserved site 2
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
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  • All nucleic 5
    Genomic 1
    cDNA 3
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 20
    Developmental Gene Expression 7
    Gene Ontology 1
    Phenotypes 3
  • Earliest
    J:93815 Ohyama T, et al., Expression of mouse Foxi class genes in early craniofacial development. Dev Dyn. 2004 Nov;231(3):640-6
  • Latest
    J:228880 Birol O, et al., The mouse Foxi3 transcription factor is necessary for the development of posterior placodes. Dev Biol. 2016 Jan 1;409(1):139-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory