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Lhfpl4 Gene Detail
Summary
  • Symbol
    Lhfpl4
  • Name
    lipoma HMGIC fusion partner-like protein 4
  • Synonyms
    1190004M23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3057108
    NCBI Gene: 269788
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:113168090-113195384 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 52.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3057108
protein coding gene Chr6:113168087-113195384 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031113
protein coding gene Chr6:115662020-115693952 (-)
A/J MGP_AJ_G0031082
protein coding gene Chr6:111242296-111269843 (-)
AKR/J MGP_AKRJ_G0031013
protein coding gene Chr6:114229259-114257753 (-)
BALB/cJ MGP_BALBcJ_G0031093
protein coding gene Chr6:111186919-111214297 (-)
C3H/HeJ MGP_C3HHeJ_G0030615
protein coding gene Chr6:70041866-70069240 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031552
protein coding gene Chr6:118665409-118697236 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028716
protein coding gene Chr6:108249490-108277323 (-)
CAST/EiJ MGP_CASTEiJ_G0030200
protein coding gene Chr6:114655553-114688517 (-)
CBA/J MGP_CBAJ_G0030779
protein coding gene Chr6:123346082-123376432 (-)
DBA/2J MGP_DBA2J_G0030932
protein coding gene Chr6:110326045-110353388 (-)
FVB/NJ MGP_FVBNJ_G0030886
protein coding gene Chr6:109317951-109346518 (-)
LP/J MGP_LPJ_G0031012
protein coding gene Chr6:115709083-115738889 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030920
protein coding gene Chr6:127627637-127658881 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031579
protein coding gene Chr6:114243805-114271645 (-)
PWK/PhJ MGP_PWKPhJ_G0029916
protein coding gene Chr6:109270750-109299017 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029744
protein coding gene Chr6:113062551-113092092 (-)
WSB/EiJ MGP_WSBEiJ_G0030284
protein coding gene Chr6:114618348-114645790 (-)



Homology
more
  • Human Ortholog
    LHFPL4, LHFPL tetraspan subfamily member 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LHFPL4, LHFPL tetraspan subfamily member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GARLH4
  • Links
    NCBI Gene ID: 375323
    neXtProt AC: NX_Q7Z7J7
    UniProt: Q7Z7J7

  • Chr Location
    3p25.3; chr3:9498361-9553802 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Endonuclease-mediated
    5
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Lhfpl4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Homozygous knockout affects inhibitory postsynaptic currents in the hippocampus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042873 Ensembl Gene Model | MGI Sequence Detail 27295 C57BL/6J ±  kb
transcript ENSMUST00000162280 Ensembl | MGI Sequence Detail 4762 Not Applicable  
polypeptide ENSMUSP00000124470 Ensembl | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 25
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916164, MGI:2141454
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:265620 Wu M, et al., Impairment of Inhibitory Synapse Formation and Motor Behavior in Mice Lacking the NL2 Binding Partner LHFPL4/GARLH4. Cell Rep. 2018 May 8;23(6):1691-1705

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory