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Nlrp4e Gene Detail
Summary
  • Symbol
    Nlrp4e
  • Name
    NLR family, pyrin domain containing 4E
  • Synonyms
    4930406H16Rik, Nalp4e, Nalp-epsilon
  • Feature Type
    protein coding gene
  • IDs
    MGI:3056600
    NCBI Gene: 446099
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:23000617-23061702 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 10.21 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    736 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3056600
protein coding gene Chr7:23000617-23061702 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031806
protein coding gene Chr7:21427827-21496962 (+)
A/J MGP_AJ_G0031782
protein coding gene Chr7:21035280-21045057 (+)
AKR/J MGP_AKRJ_G0031708
protein coding gene Chr7:21542145-21549546 (+)
BALB/cJ MGP_BALBcJ_G0031787
protein coding gene Chr7:21247114-21254033 (+)
C3H/HeJ MGP_C3HHeJ_G0031509
protein coding gene Chr7:21855510-21874370 (+)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030852
protein coding gene Chr7:15457641-15465100 (+)
CBA/J MGP_CBAJ_G0031471
protein coding gene Chr7:23020812-23028533 (+)
DBA/2J MGP_DBA2J_G0031626
protein coding gene Chr7:20975570-20982788 (+)
FVB/NJ MGP_FVBNJ_G0031578
protein coding gene Chr7:20885252-20950856 (+)
LP/J MGP_LPJ_G0031708
protein coding gene Chr7:21839883-21848341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031614
protein coding gene Chr7:22900192-22911029 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032281
protein coding gene Chr7:21241062-21251937 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0030952
protein coding gene Chr7:21432894-21439589 (+)



Homology
more
  • Human Ortholog
    NLRP4, NLR family pyrin domain containing 4
  • Vertebrate Orthologs
    101
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NLRP4, NLR family pyrin domain containing 4
  • Synonyms
    CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2
  • Links
    NCBI Gene ID: 147945
    neXtProt AC: NX_Q96MN2
    UniProt: Q96MN2

  • Chr Location
    19q13.43; chr19:55836540-55881855 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 446099 NCBI Gene Model | MGI Sequence Detail 61086 C57BL/6J ±  kb
transcript NM_001004194 RefSeq | MGI Sequence Detail 3382 C57BL/6  
polypeptide Q66X19 UniProt | EBI | MGI Sequence Detail 978 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:1925402
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:248785 Lin M, et al., USP38 Inhibits Type I Interferon Signaling by Editing TBK1 Ubiquitination through NLRP4 Signalosome. Mol Cell. 2016 Oct 20;64(2):267-281

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory