Ggnbp1 MGI Mouse Gene Detail - MGI:3055306 - gametogenetin binding protein 1

Symbol

Ggnbp1
Name

gametogenetin binding protein 1
Synonyms

0610031G08Rik

Feature Type

protein coding gene
IDs

MGI:3055306
NCBI Gene: 70772
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:27237009-27255352 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 13.60 cM, cytoband B1
Mapping Data

3 experiments

SNPs within 2kb

83 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3055306	protein coding gene	Chr17:27236961-27256598 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023414	protein coding gene	Chr17:26204395-26277760 (+)
A/J	MGP_AJ_G0023371	protein coding gene	Chr17:25404646-25470629 (+)
AKR/J	MGP_AKRJ_G0023337	protein coding gene	Chr17:25538565-25607553 (+)
BALB/cJ	MGP_BALBcJ_G0023376	protein coding gene	Chr17:25647637-25720586 (+)
C3H/HeJ	MGP_C3HHeJ_G0023137	protein coding gene	Chr17:25913991-25988088 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023819	protein coding gene	Chr17:27307936-27383064 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021293	protein coding gene	Chr17:22814291-22884533 (+)
CAST/EiJ	MGP_CASTEiJ_G0022638	protein coding gene	Chr17:25842420-25912736 (+)
CBA/J	MGP_CBAJ_G0023111	protein coding gene	Chr17:28258283-28333081 (+)
DBA/2J	MGP_DBA2J_G0023243	protein coding gene	Chr17:24966843-25033298 (+)
FVB/NJ	MGP_FVBNJ_G0023212	protein coding gene	Chr17:24752522-24817398 (+)
LP/J	MGP_LPJ_G0023320	protein coding gene	Chr17:26453137-26523063 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023230	protein coding gene	Chr17:27778638-27855672 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023860	protein coding gene	Chr17:25910355-25981878 (+)
PWK/PhJ	MGP_PWKPhJ_G0022388	protein coding gene	Chr17:23765151-23833780 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022206	protein coding gene	Chr17:23948515-24018683 (+)
WSB/EiJ	MGP_WSBEiJ_G0022701	protein coding gene	Chr17:25934692-26008780 (+)

Human Ortholog

GGNBP1, gametogenetin binding protein 1 (pseudogene)

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GGNBP1, gametogenetin binding protein 1 (pseudogene)
Links

HGNC:19427

NCBI Gene ID: 449520

UniProt: Q5YKI7
Chr Location

6p21.31; chr6:33540046-33589026 (+) GRCh38

MGI Vertebrate Homology

Ggnbp1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: GGNBP1
Gene Tree

Ggnbp1

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Radiation induced

2
Targeted

3
Genomic Mutations

2 involving Ggnbp1
Incidental Mutations

CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit male infertility, asthenozoospermia, and teratozoospermia in a portion of mice and increased sensitivity to BPA-induced sperm damage.

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

4
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

59
RefSeq

4
UniProt

6
CCDS

CCDS28559.1, CCDS57061.1

Ensembl

ENSMUSG00000048731 (Evidence)
NCBI Gene

70772

			Length	Strain/Species	Flank
genomic	70772	NCBI Gene Model \| MGI Sequence Detail	18344	C57BL/6J	± kb
transcript	NM_027544	RefSeq \| MGI Sequence Detail	1525	C57BL/6
polypeptide	Q6K1E7	UniProt \| EBI \| MGI Sequence Detail	370	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007959 putative gametogenetin-binding protein 1

(term hierarchy)
InterPro Domains

IPR028135 Ubiquitin-like domain, USP-type

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All nucleic 8

cDNA 8

Microarray probesets 4

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MGI:1922643

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:297928 Han T, et al., GGNBP1 ensures proper spermiogenesis in response to stress in mice. Biochem Biophys Res Commun. 2020 May 7;525(3):706-713

TSS for Ggnbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143297	Chr17:27236966-27236977 (+)	-37 bp
Tssr143298	Chr17:27236979-27237041 (+)	1 bp
Tssr143299	Chr17:27248336-27248340 (+)	11,329 bp
Tssr143300	Chr17:27248343-27248389 (+)	11,357 bp
Tssr143301	Chr17:27248392-27248398 (+)	11,386 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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