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Noto Gene Detail
Summary
  • Symbol
    Noto
  • Name
    notochord homeobox
  • Synonyms
    Flh, MmNot, Not, tc
  • Feature Type
    protein coding gene
  • IDs
    MGI:3053002
    NCBI Gene: 384452
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr6:85400868-85405859 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.44 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3053002
protein coding gene Chr6:85400851-85405859 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030952
protein coding gene Chr6:86589394-86595480 (+)
A/J MGP_AJ_G0030921
protein coding gene Chr6:83291825-83297320 (+)
AKR/J MGP_AKRJ_G0030849
protein coding gene Chr6:85704631-85709533 (+)
BALB/cJ MGP_BALBcJ_G0030931
protein coding gene Chr6:83284516-83289493 (+)
C3H/HeJ MGP_C3HHeJ_G0030779
protein coding gene Chr6:98735616-98741437 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031391
protein coding gene Chr6:88972442-88979979 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028576
protein coding gene Chr6:81565700-81571014 (+)
CAST/EiJ MGP_CASTEiJ_G0030040
protein coding gene Chr6:85719502-85724383 (+)
CBA/J MGP_CBAJ_G0030618
protein coding gene Chr6:92462324-92469101 (+)
DBA/2J MGP_DBA2J_G0030771
protein coding gene Chr6:82575132-82580451 (+)
FVB/NJ MGP_FVBNJ_G0030724
protein coding gene Chr6:81777693-81782796 (+)
LP/J MGP_LPJ_G0030850
protein coding gene Chr6:86584317-86591081 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030760
protein coding gene Chr6:96668345-96673768 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031415
protein coding gene Chr6:85506678-85511589 (+)
PWK/PhJ MGP_PWKPhJ_G0029755
protein coding gene Chr6:81510310-81515681 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029583
protein coding gene Chr6:84360365-84366242 (+)
WSB/EiJ MGP_WSBEiJ_G0030121
protein coding gene Chr6:85952361-85957254 (+)



Homology
more
  • Human Ortholog
    NOTO, notochord homeobox
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOTO, notochord homeobox
  • Links
    NCBI Gene ID: 344022
    neXtProt AC: NX_A8MTQ0
    UniProt: A8MTQ0

  • Chr Location
    2p13.2; chr2:73202258-73211212 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 5 alleles in 8 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice display decreased tail length, a truncated or disrupted notochord, abnormal and missing vertebrae, occasional hindlimb paralysis and postnatal lethality, and abnormal somite and sclerotome development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068302 Ensembl Gene Model | MGI Sequence Detail 4992 C57BL/6J ±  kb
    transcript ENSMUST00000089578 Ensembl | MGI Sequence Detail 1602 Not Applicable  
    polypeptide ENSMUSP00000087006 Ensembl | MGI Sequence Detail 240 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 7
      Primer pair 1
      Other 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-14735, MGI:98498
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 19
      Gene Ontology 12
      Phenotypes 25
    • Earliest
      J:14910 Theiler K, Boneless tail, ein rezessives autosomales Gen der Hausmaus. Arch Julius Klaus Stift Vererbungsforsch Sozialanthropol Rassenhyg. 1957;32:474-481
    • Latest
      J:301045 Guo SS, et al., beta1 Integrin regulates convergent extension in mouse notogenesis, ensures notochord integrity and the morphogenesis of vertebrae and intervertebral discs. Development. 2020 Nov 18;147(22)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    09/07/2021
    MGI 6.17
    The Jackson Laboratory