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Noto Gene Detail
Summary
  • Symbol
    Noto
  • Name
    notochord homeobox
  • Synonyms
    Flh, MmNot, Not, tc
  • Feature Type
    protein coding gene
  • IDs
    MGI:3053002
    NCBI Gene: 384452
Location & Maps
more
  • Sequence Map
    Chr6:85423886-85428877 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4992 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.44 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    NOTO, notochord homeobox
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NOTO, notochord homeobox
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 344022
    neXtProt AC: NX_A8MTQ0

  • Chr Location
    2p13.2; chr2:73202258-73211212 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 5 alleles in 8 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Spontaneous
    2
  • Targeted
    8
  • Genomic Mutations
    1 involving Noto
  • Incidental Mutations
    APF
Homozygous mutant mice display decreased tail length, a truncated or disrupted notochord, abnormal and missing vertebrae, occasional hindlimb paralysis and postnatal lethality, and abnormal somite and sclerotome development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037550 VEGA Gene Model | MGI Sequence Detail 4992 C57BL/6J ±  kb
transcript OTTMUST00000096804 VEGA | MGI Sequence Detail 1602 Not Applicable  
polypeptide OTTMUSP00000054125 VEGA | MGI Sequence Detail 240 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    18 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 7
    cDNA 5
    Primer pair 1
    Other 1

    Microarray probesets 1
Other
Accession IDs
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MGD-MRK-14735, MGI:98498
References
more
  • Summaries
    All 41
    Developmental Gene Expression 13
    Gene Ontology 10
    Phenotypes 20
  • Earliest
    J:64444 Griffen A, tc - truncate. Mouse News Lett. 1951;5:31
  • Latest
    J:220460 Andre P, et al., Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory