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Fbxl7 Gene Detail
Summary
  • Symbol
    Fbxl7
  • Name
    F-box and leucine-rich repeat protein 7
  • Synonyms
    D230018M15Rik, Fbl6, FBL7
  • Feature Type
    protein coding gene
  • IDs
    MGI:3052506
    NCBI Gene: 448987
  • Gene Overview
    MyGene.info: FBXL7
Location & Maps
more
  • Sequence Map
    Chr15:26543084-26895049 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      351966 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 9.87 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FBXL7, F-box and leucine rich repeat protein 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBXL7, F-box and leucine rich repeat protein 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBL6, FBL7
  • Links
    NCBI Gene ID: 23194
    neXtProt AC: NX_Q9UJT9

  • Chr Location
    5p15.1; chr5:15500165-15939796 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 69121
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FBXL7
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Targeted
    2
  • Genomic Mutations
    2 involving Fbxl7
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043556 Ensembl Gene Model | MGI Sequence Detail 351966 C57BL/6J ±  kb
transcript ENSMUST00000059204 Ensembl | MGI Sequence Detail 1476 Not Applicable  
polypeptide ENSMUSP00000061305 Ensembl | MGI Sequence Detail 491 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2115 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007385 F-box/LRR-repeat protein 7
  • InterPro Domains
    IPR001810 F-box domain
    IPR001611 Leucine-rich repeat
    IPR006553 Leucine-rich repeat, cysteine-containing subtype
    IPR032675 Leucine-rich repeat domain, L domain-like
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 7
Other
Accession IDs
less
MGI:2146117, MGI:2442376
References
more
  • Summaries
    All 25
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:184734 Coon TA, et al., Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest. Cell Cycle. 2012 Feb 15;11(4):721-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory