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Fbxl7 Gene Detail
Summary
  • Symbol
    Fbxl7
  • Name
    F-box and leucine-rich repeat protein 7
  • Synonyms
    D230018M15Rik, Fbl6, FBL7
  • Feature Type
    protein coding gene
  • IDs
    MGI:3052506
    NCBI Gene: 448987
  • Gene Overview
    MyGene.info: FBXL7
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:26540454-26895564 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 9.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2120 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3052506
protein coding gene Chr15:26540454-26895580 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021754
protein coding gene Chr15:24567919-24935757 (-)
A/J MGP_AJ_G0021714
protein coding gene Chr15:23643763-23998059 (-)
AKR/J MGP_AKRJ_G0021692
protein coding gene Chr15:24172474-24546650 (-)
BALB/cJ MGP_BALBcJ_G0021721
protein coding gene Chr15:23612183-23965708 (-)
C3H/HeJ MGP_C3HHeJ_G0021497
protein coding gene Chr15:24216530-24578186 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022160
protein coding gene Chr15:25623531-25988201 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019700
protein coding gene Chr15:21938567-22330124 (-)
CAST/EiJ MGP_CASTEiJ_G0021013
protein coding gene Chr15:24584392-24965243 (-)
CBA/J MGP_CBAJ_G0021466
protein coding gene Chr15:26390258-26739687 (-)
DBA/2J MGP_DBA2J_G0021590
protein coding gene Chr15:23391508-23749064 (-)
FVB/NJ MGP_FVBNJ_G0021568
protein coding gene Chr15:22952883-23312144 (-)
LP/J MGP_LPJ_G0021658
protein coding gene Chr15:24438704-24799606 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021593
protein coding gene Chr15:29135610-29500039 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022183
protein coding gene Chr15:24378527-24744219 (-)
PWK/PhJ MGP_PWKPhJ_G0020756
protein coding gene Chr15:23551633-23913123 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020594
protein coding gene Chr15:24182799-24555667 (-)
WSB/EiJ MGP_WSBEiJ_G0021069
protein coding gene Chr15:24365937-24729815 (-)



Homology
more
  • Human Ortholog
    FBXL7, F-box and leucine rich repeat protein 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FBXL7, F-box and leucine rich repeat protein 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FBL6, FBL7
  • Links
    NCBI Gene ID: 23194
    neXtProt AC: NX_Q9UJT9
    UniProt: Q9UJT9

  • Chr Location
    5p15.1; chr5:15500196-15939796 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 69121
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: FBXL7
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 448987 NCBI Gene Model | MGI Sequence Detail 355111 C57BL/6J ±  kb
transcript NM_176959 RefSeq | MGI Sequence Detail 4639 C57BL/6  
polypeptide Q5BJ29 UniProt | EBI | MGI Sequence Detail 491 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 7
Other
Accession IDs
less
MGI:2146117, MGI:2442376
References
more
  • Summaries
    All 34
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:184734 Coon TA, et al., Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest. Cell Cycle. 2012 Feb 15;11(4):721-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory