Fbxw10 Gene Detail

Summary

• Symbol
  Fbxw10
• Name
  F-box and WD-40 domain protein 10
• Synonyms
  Fbw10, SM25H2, SM2SH2

• Feature Type
  protein coding gene
• IDs
  MGI:3052463
  NCBI Gene: 213980

Location & Maps

• Sequence Map
  Chr11:62847069-62877465 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    30397 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 38.78 cM
• Mapping Data
  1 experiment

Homology

• Human Ortholog
  CDRT1, CMT1A duplicated region transcript 1

• Vertebrate Orthologs
  8

• Human Ortholog
  CDRT1, CMT1A duplicated region transcript 1
  Orthology source: HGNC
• Synonyms
  C170RF1, C17ORF1, C17ORF1A, FBXW10B, FBXW10P1, HREP, SM25H2
• Links
  HGNC:14379

  NCBI Gene ID: 374286

  neXtProt AC: NX_O95170

  
  
• Chr Location
  17p12; chr17:15565482-15619704 (-)  GRCh38.p2

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• Human Ortholog
  FBXW10, F-box and WD repeat domain containing 10
  Orthology source: HomoloGene, HGNC
• Synonyms
  Fbw10, HREP, SM25H2, SM2SH2
• Links
  HGNC:1211

  NCBI Gene ID: 10517

  neXtProt AC: NX_Q5XX13

  
  
• Chr Location
  17p12; chr17:18740223-18779349 (+)  GRCh38.p2

---

• HomoloGene
  Vertebrate Homology Class 32757
  1 human;1 mouse;1 rat;1 rhesus macaque;1 cattle;1 dog;1 zebrafish;1 frog, western clawed
  
• HCOP
  human homology predictions: CDRT1, FBXW10
• Gene Tree
  Fbxw10
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  5 phenotype references
  

• All Mutations and Alleles
  5
• Chemically induced (other)
  1
• Gene trapped
  3
• Targeted
  1
• Genomic Mutations
  1 involving Fbxw10
• Incidental Mutations
  Mutagenetix , APF

Gene Ontology
(GO)
Classifications

• External Resources
  FuncBase

Expression

• cDNA Data
  13

• Other Mouse Links
  Allen Institute
  GEO

Interactions

• Fbxw10 interacts with 192 markers (Mir1a-1, Mir1a-2, Mir10a, ...) View All

Sequences &
Gene Models

• All Sequences
  44
• RefSeq
  10
• UniProt
  5
• CCDS
  CCDS24833.2, CCDS78968.1
• UniGene
  482259

• VEGA
  OTTMUSG00000005877 (Evidence)
• Ensembl
  ENSMUSG00000090173 (Evidence)
• NCBI Gene
  213980

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000005877	VEGA Gene Model | MGI Sequence Detail	30397	C57BL/6J
transcript	OTTMUST00000013089	VEGA | MGI Sequence Detail	3354	Not Applicable
polypeptide	OTTMUSP00000006077	VEGA | MGI Sequence Detail	1030	Not Applicable

Polymorphisms

• SNPs within 2kb
  270 from dbSNP Build 142

Protein
Information

• UniProt
  5 Sequences
• InterPro Domains
  IPR001810 F-box domain
  IPR020472 G-protein beta WD-40 repeat
  IPR001680 WD40 repeat
  IPR017986 WD40-repeat-containing domain
  IPR015943 WD40/YVTN repeat-like-containing domain

Molecular
Reagents

• All nucleic 14

  Genomic 1

  cDNA 13

  
  

  Microarray probesets 2

References

• Summaries
  All 20

  Phenotypes 5
• Earliest
  J:93441 Jin J, et al., Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 2004 Dec 1;18(21):2573-80
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582