Fbxw10 MGI Mouse Gene Detail - MGI:3052463 - F-box and WD-40 domain protein 10

Symbol

Fbxw10
Name

F-box and WD-40 domain protein 10
Synonyms

Fbw10, SM25H2, SM2SH2

Feature Type

protein coding gene
IDs

MGI:3052463
NCBI Gene: 213980
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:62737895-62768291 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 38.78 cM
Mapping Data

1 experiment

SNPs within 2kb

1932 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3052463	protein coding gene	Chr11:62737893-62768291 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018464	protein coding gene	Chr11:62936355-62971827 (+)
A/J	MGP_AJ_G0018433	protein coding gene	Chr11:60593267-60627697 (+)
AKR/J	MGP_AKRJ_G0018402	protein coding gene	Chr11:62460691-62494280 (+)
BALB/cJ	MGP_BALBcJ_G0018404	protein coding gene	Chr11:60871527-60902383 (+)
C3H/HeJ	MGP_C3HHeJ_G0018217	protein coding gene	Chr11:62435978-62467134 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018856	protein coding gene	Chr11:64901883-64936326 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016500	protein coding gene	Chr11:57673345-57703781 (+)
CAST/EiJ	MGP_CASTEiJ_G0017773	protein coding gene	Chr11:62593822-62627596 (+)
CBA/J	MGP_CBAJ_G0018191	protein coding gene	Chr11:67696963-67736457 (+)
DBA/2J	MGP_DBA2J_G0018300	protein coding gene	Chr11:60145019-60176739 (+)
FVB/NJ	MGP_FVBNJ_G0018290	protein coding gene	Chr11:59813365-59843729 (+)
LP/J	MGP_LPJ_G0018372	protein coding gene	Chr11:63464636-63498695 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018314	protein coding gene	Chr11:68684228-68717080 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018897	protein coding gene	Chr11:62619346-62650475 (+)
PWK/PhJ	MGP_PWKPhJ_G0017547	protein coding gene	Chr11:60765011-60796803 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017337	protein coding gene	Chr11:62468663-62504067 (+)
WSB/EiJ	MGP_WSBEiJ_G0017826	protein coding gene	Chr11:62236011-62269487 (+)

Human Ortholog

FBXW10, F-box and WD repeat domain containing 10

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXW10, F-box and WD repeat domain containing 10
Synonyms

Fbw10, HREP, SM25H2, SM2SH2
Links

HGNC:1211

NCBI Gene ID: 10517

UniProt: Q5XX13
Chr Location

17p11.2; chr17:18744026-18779349 (+) GRCh38

Human Ortholog

FBXW10B, F-box and WD repeat domain containing 10B
Synonyms

C170RF1, C17ORF1, C17ORF1A, CDRT1, FBXW10P1, HREP, SM25H2
Links

HGNC:14379

NCBI Gene ID: 374286

UniProt: O95170
Chr Location

17p12; chr17:15565482-15619704 (-) GRCh38

MGI Vertebrate Homology

Fbxw10 stringent orthology
2 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXW10, FBXW10B
Gene Tree

Fbxw10

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Targeted

1
Genomic Mutations

1 involving Fbxw10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

61 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

14

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

60
RefSeq

18
UniProt

5
CCDS

CCDS24833.2, CCDS78968.1

Ensembl

ENSMUSG00000090173 (Evidence)
NCBI Gene

213980

			Length	Strain/Species	Flank
genomic	ENSMUSG00000090173	Ensembl Gene Model \| MGI Sequence Detail	30397	C57BL/6J	± kb
transcript	ENSMUST00000036085	Ensembl \| MGI Sequence Detail	3354	Not Applicable
polypeptide	ENSMUSP00000046156	Ensembl \| MGI Sequence Detail	1030	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR001810 F-box domain

IPR036047 F-box-like domain superfamily

IPR020472 G-protein beta WD-40 repeat

IPR051075 SCF complex subunit WD repeat-containing protein

IPR001680 WD40 repeat

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 15

Genomic 1

cDNA 14

Microarray probesets 2

Summaries

All 31

Gene Ontology 1

Phenotypes 10
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbxw10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102067	Chr11:62737888-62737913 (+)	6 bp
Tssr102068	Chr11:62737916-62737929 (+)	28 bp
Tssr102069	Chr11:62737937-62737958 (+)	53 bp
Tssr102070	Chr11:62752935-62752940 (+)	15,043 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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