Fbxw10 Gene Detail

Summary

• Symbol
  Fbxw10
• Name
  F-box and WD-40 domain protein 10
• Synonyms
  Fbw10, SM25H2, SM2SH2

• Feature Type
  protein coding gene
• IDs
  MGI:3052463
  NCBI Gene: 213980
• Alliance
  gene page
• Transcription Start Sites
  3 TSS

Location &
Maps

• Sequence Map
  Chr11:62847069-62877465 bp, + strand
• From Ensembl annotation of GRCm38
  

  View this region in JBrowse
  
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 38.78 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  270 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3052463	protein coding gene	Chr11:62847067-62877465 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018464	protein coding gene	Chr11:62936355-62971827 (+)
A/J	MGP_AJ_G0018433	protein coding gene	Chr11:60593267-60627697 (+)
AKR/J	MGP_AKRJ_G0018402	protein coding gene	Chr11:62460691-62494280 (+)
BALB/cJ	MGP_BALBcJ_G0018404	protein coding gene	Chr11:60871527-60902383 (+)
C3H/HeJ	MGP_C3HHeJ_G0018217	protein coding gene	Chr11:62435978-62467134 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018856	protein coding gene	Chr11:64901883-64936326 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016500	protein coding gene	Chr11:57673345-57703781 (+)
CAST/EiJ	MGP_CASTEiJ_G0017773	protein coding gene	Chr11:62593822-62627596 (+)
CBA/J	MGP_CBAJ_G0018191	protein coding gene	Chr11:67696963-67736457 (+)
DBA/2J	MGP_DBA2J_G0018300	protein coding gene	Chr11:60145019-60176739 (+)
FVB/NJ	MGP_FVBNJ_G0018290	protein coding gene	Chr11:59813365-59843729 (+)
LP/J	MGP_LPJ_G0018372	protein coding gene	Chr11:63464636-63498695 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018314	protein coding gene	Chr11:68684228-68717080 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018897	protein coding gene	Chr11:62619346-62650475 (+)
PWK/PhJ	MGP_PWKPhJ_G0017547	protein coding gene	Chr11:60765011-60796803 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017337	protein coding gene	Chr11:62468663-62504067 (+)
WSB/EiJ	MGP_WSBEiJ_G0017826	protein coding gene	Chr11:62236011-62269487 (+)

Homology

• Human Ortholog
  CDRT1, CMT1A duplicated region transcript 1

• Vertebrate Orthologs
  8

• Human Ortholog
  CDRT1, CMT1A duplicated region transcript 1
  Orthology source: HGNC
• Synonyms
  C170RF1, C17ORF1, C17ORF1A, FBXW10B, FBXW10P1, HREP, SM25H2
• Links
  HGNC:14379

  NCBI Gene ID: 374286

  neXtProt AC: NX_O95170

  UniProt: O95170

  
  
• Chr Location
  17p12; chr17:15565482-15619704 (-)  GRCh38.p7

---

• Human Ortholog
  FBXW10, F-box and WD repeat domain containing 10
  Orthology source: HomoloGene, HGNC
• Synonyms
  Fbw10, HREP, SM25H2, SM2SH2
• Links
  HGNC:1211

  NCBI Gene ID: 10517

  neXtProt AC: NX_Q5XX13

  UniProt: Q5XX13

  
  
• Chr Location
  17p11.2; chr17:18744013-18779349 (+)  GRCh38.p7

---

• HomoloGene
  Vertebrate Homology Class 32757
  1 human;1 mouse;1 rat;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: CDRT1, FBXW10
• Gene Tree
  Fbxw10
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  6 phenotype references
  

• All Mutations and Alleles
  6
• Chemically induced (other)
  1
• Endonuclease-mediated
  1
• Gene trapped
  3
• Targeted
  1
• Genomic Mutations
  1 involving Fbxw10
• Incidental Mutations
  Mutagenetix , APF
• Find Mice (IMSR)
  31 strains or lines available

Gene Ontology
(GO)
Classifications

• External Resources
  FuncBase

Expression

• cDNA Data
  14

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Interactions

• Fbxw10 interacts with 192 markers (Mir1a-1, Mir1a-2, Mir10a, ...) View All

Sequences &
Gene Models

• All Sequences
  52
• RefSeq
  10
• UniProt
  5
• CCDS
  CCDS24833.2, CCDS78968.1
• UniGene
  482259

• Ensembl
  ENSMUSG00000090173 (Evidence)
• NCBI Gene
  213980

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000090173	Ensembl Gene Model | MGI Sequence Detail	30397	C57BL/6J
transcript	ENSMUST00000036085	Ensembl | MGI Sequence Detail	3354	Not Applicable
polypeptide	ENSMUSP00000046156	Ensembl | MGI Sequence Detail	1030	Not Applicable

Protein
Information

• UniProt
  5 Sequences
• InterPro Domains
  IPR036047 F-box-like domain superfamily
  IPR020472 G-protein beta WD-40 repeat
  IPR001680 WD40 repeat
  IPR017986 WD40-repeat-containing domain
  IPR036322 WD40-repeat-containing domain superfamily
  IPR015943 WD40/YVTN repeat-like-containing domain superfamily

Molecular
Reagents

• All nucleic 15

  Genomic 1

  cDNA 14

  
  

  Microarray probesets 2

References

• Summaries
  All 24

  Phenotypes 6
• Earliest
  J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
• Latest
  J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

TSS for Fbxw10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102067	Chr11:62847062-62847087 (+)	6 bp
Tssr102068	Chr11:62847090-62847103 (+)	28 bp
Tssr102069	Chr11:62847111-62847132 (+)	53 bp