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Ank
Gene Detail
 Symbol
Name
ID
Ank
progressive ankylosis
MGI:3045421
Synonyms D15Ertd221e, mKIAA1581
Feature Type protein coding gene
Genetic Map
Chromosome 15
10.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr15:27466677-27594909 bp, + strand
From VEGA annotation of GRCm38

  128233 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10664  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ank

Human
homologs
Human Homolog ANKH, ANKH inorganic pyrophosphate transport regulator
NCBI Gene ID 56172
neXtProt AC  NX_Q9HCJ1
Human Synonyms  ANK, CCAL2, CMDJ, CPPDD, HANK, MANK
Human Chr (Location)  5p15.1; chr5:14704800-14871778 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ANKH
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(1) Spontaneous(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant animals exhibit joint stiffness due to increased calcium deposits in calcified cartilages and die prematurely. Hyperostosis of craniofacial bones and the mandible has been reported in other mutants as well.
 
Human Diseases Modeled Using Mouse Ank (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Ank interacts with 249 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process inorganic diphosphate transport, ion transmembrane transport, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function inorganic diphosphate transmembrane transporter activity, inorganic phosphate transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (32)    Tissues (25)   
Theiler Stages: 23, 25, 28
Assay TypeResults
RNA in situ 31
Northern blot 1
cDNA source data(133)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(138) Genomic(1) cDNA(134) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026300 (Evidence)
Ensembl Gene ModelENSMUSG00000022265 (Evidence)
Entrez Gene11732 (Evidence)
UniGene265264
DFCITC1573067
DoTSDT.489949
NIA Mouse Gene IndexU016123
Consensus CDS ProjectCCDS27402.1
International Mouse Knockout Project StatusAnk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026300 VEGA Gene Model | MGI Sequence Detail 128233 C57BL/6J ±  kb
transcript OTTMUST00000065059 VEGA | MGI Sequence Detail 3498 Not Applicable 
polypeptide OTTMUSP00000032371 VEGA | MGI Sequence Detail 492 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(1298 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009887 Progressive ankylosis
Protein Ontology PR:000004036 progressive ankylosis protein
References (Earliest) J:6580 Sweet HO, et al., Progressive ankylosis, a new skeletal mutation in the mouse. J Hered. 1981 Mar-Apr;72(2):87-93
(Latest) J:199427 Yuki KE, et al., Suppression of hepcidin expression and iron overload mediate Salmonella susceptibility in ankyrin 1 ENU-induced mutant. PLoS One. 2013;8(2):e55331
All references(69)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1323, MGI:1098556, MGI:88023

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory