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Lin52 Gene Detail
Summary
  • Symbol
    Lin52
  • Name
    lin-52 homolog (C. elegans)
  • Synonyms
    5830457H20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045391
    NCBI Gene: 217708
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr12:84451422-84546145 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 39.22 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    514 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045391
protein coding gene Chr12:84451119-84546515 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0019896
protein coding gene Chr12:81935700-82019561 (+)
AKR/J MGP_AKRJ_G0019872
protein coding gene Chr12:84152690-84235078 (+)
BALB/cJ MGP_BALBcJ_G0019876
protein coding gene Chr12:82268523-82347992 (+)
C3H/HeJ MGP_C3HHeJ_G0019682
protein coding gene Chr12:84618837-84652081 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020327
protein coding gene Chr12:87612969-87704015 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017945
protein coding gene Chr12:78836179-78919528 (+)
CAST/EiJ MGP_CASTEiJ_G0019231
protein coding gene Chr12:79576899-79661680 (+)
CBA/J MGP_CBAJ_G0019653
protein coding gene Chr12:90996096-91080591 (+)
DBA/2J MGP_DBA2J_G0019768
protein coding gene Chr12:81464904-81545677 (+)
FVB/NJ MGP_FVBNJ_G0019754
protein coding gene Chr12:80420767-80499586 (+)
LP/J MGP_LPJ_G0019179
protein coding gene Chr11:108211850-108213686 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019793
protein coding gene Chr12:93903976-93925396 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020361
protein coding gene Chr12:83746329-83834293 (+)
PWK/PhJ MGP_PWKPhJ_G0018995
protein coding gene Chr12:75955529-76036212 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018790
protein coding gene Chr12:78242491-78326014 (+)
WSB/EiJ MGP_WSBEiJ_G0018632
protein coding gene Chr11:106716435-106719458 (+)



Homology
more
  • Human Ortholog
    LIN52, lin-52 DREAM MuvB core complex component
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LIN52, lin-52 DREAM MuvB core complex component
    Orthology source: HomoloGene, HGNC
  • Synonyms
    c14_5549, C14orf46
  • Links
    NCBI Gene ID: 91750
    neXtProt AC: NX_Q52LA3
    UniProt: Q52LA3

  • Chr Location
    14q24.3; chr14:74084831-74201255 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 15655
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: LIN52
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000085793 Ensembl Gene Model | MGI Sequence Detail 94724 C57BL/6J ±  kb
transcript ENSMUST00000137170 Ensembl | MGI Sequence Detail 2270 Not Applicable  
polypeptide ENSMUSP00000133045 Ensembl | MGI Sequence Detail 116 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    cDNA 39

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:85162 Hansen J, et al., A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9918-22
  • Latest
    J:237827 Gineste C, et al., In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Neuromuscul Disord. 2013 Apr;23(4):357-69

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory