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Defb22 Gene Detail
Summary
  • Symbol
    Defb22
  • Name
    defensin beta 22
  • Synonyms
    9230002F21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045368
    NCBI Gene: 442835
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:152327586-152332058 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 75.13 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045368
 protein coding gene Chr2:152327583-152332058 (-)
129S1/SvImJ ENSMUSG00200029611
 protein coding gene Chr2:149227475-149231924 (-)
A/J ENSMUSG00195017355
 protein coding gene Chr2:149511659-149516128 (-)
AKR/J ENSMUSG00220043988
 protein coding gene Chr2:148836241-148840722 (-)
BALB/cJ ENSMUSG00180038748
 protein coding gene Chr2:148997713-149002192 (-)
C3H/HeJ ENSMUSG00175040503
 protein coding gene Chr2:149743942-149748419 (-)
C57BL/6NJ ENSMUSG00215019304
 protein coding gene Chr2:149170916-149175391 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024458
 protein coding gene Chr2:144363743-144368226 (-)
CAST/EiJ ENSTCUG00005039222
 protein coding gene Chr2:148095458-148099925 (-)
CBA/J ENSMUSG00210043616
 protein coding gene Chr2:149680435-149684908 (-)
DBA/2J ENSMUSG00185046328
 protein coding gene Chr2:149330934-149335411 (-)
FVB/NJ ENSMUSG00205023445
 protein coding gene Chr2:148427695-148432172 (-)
JF1/MsJ ENSUMUG00000045648
 protein coding gene Chr2:149000227-149004732 (-)
LP/J ENSMUSG00230033091
 protein coding gene Chr2:150979878-150984327 (-)
NOD/ShiLtJ ENSMUSG00190034621
 protein coding gene Chr2:149099661-149104130 (-)
NZO/HlLtJ ENSMUSG00225004516
 protein coding gene Chr2:159019090-159023565 (-)
PWK/PhJ ENSLUMG00010038165
 protein coding gene Chr2:148969319-148973780 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005046209
 protein coding gene Chr2:148834993-148839456 (-)



Homology
more
  • Human Ortholog
    DEFB126, defensin beta 126
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB126, defensin beta 126
  • Synonyms
    bA530N10.1, C20orf8, DEFB-26, DEFB26, hBD-26, HBD26
  • Links
    NCBI Gene ID: 81623
    UniProt: Q9BYW3

  • Chr Location
    20p13; chr20:142590-145751 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Defb22
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    16 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 442835 NCBI Gene Model | MGI Sequence Detail 4473 C57BL/6J ±  kb
transcript NM_001002791 RefSeq | MGI Sequence Detail 625 Not Specified  
polypeptide Q8BVC1 UniProt | EBI | MGI Sequence Detail 179 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR025933 Beta-defensin domain
Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 30
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory