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Adamts3 Gene Detail
Summary
  • Symbol
    Adamts3
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3
  • Synonyms
    1100001H14Rik, 6330442E02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045353
    NCBI Gene: 330119
  • Gene Overview
    MyGene.info: ADAMTS3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:89677087-89883334 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      206248 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 44.32 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ADAMTS3, ADAM metallopeptidase with thrombospondin type 1 motif 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAMTS3, ADAM metallopeptidase with thrombospondin type 1 motif 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADAMTS-4
  • Links
    NCBI Gene ID: 9508
    neXtProt AC: NX_O15072
    UniProt: O15072

  • Chr Location
    4q13.3; chr4:72280969-72568799 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    57 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit lethality after E15, edema, absent lymphatic vessels, liver degeneration, and abnormal placenta labyrinth morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000055409 VEGA Gene Model | MGI Sequence Detail 206248 C57BL/6J ±  kb
    transcript OTTMUST00000137169 VEGA | MGI Sequence Detail 3937 Not Applicable  
    polypeptide OTTMUSP00000072290 VEGA | MGI Sequence Detail 1204 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1621 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR010294 ADAM-TS Spacer 1
      IPR024079 Metallopeptidase, catalytic domain superfamily
      IPR001590 Peptidase M12B, ADAM/reprolysin
      IPR002870 Peptidase M12B, propeptide
      IPR000884 Thrombospondin type-1 (TSP1) repeat
      IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 16
    Other
    Accession IDs
    less
    MGI:1915676
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory