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Adamts3 Gene Detail
Summary
  • Symbol
    Adamts3
  • Name
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3
  • Synonyms
    1100001H14Rik, 6330442E02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045353
    NCBI Gene: 330119
  • Gene Overview
    MyGene.info: ADAMTS3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:89677087-89883334 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 44.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1621 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045353
protein coding gene Chr5:89673841-89883674 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029717
protein coding gene Chr5:90696635-90918924 (-)
A/J MGP_AJ_G0029683
protein coding gene Chr5:87124458-87337718 (-)
AKR/J MGP_AKRJ_G0029629
protein coding gene Chr5:89997303-90206180 (-)
BALB/cJ MGP_BALBcJ_G0029693
protein coding gene Chr5:88038928-88246170 (-)
C3H/HeJ MGP_C3HHeJ_G0029416
protein coding gene Chr5:90353719-90565248 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030147
protein coding gene Chr5:94365843-94571455 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027383
protein coding gene Chr5:82882625-83090097 (-)
CAST/EiJ MGP_CASTEiJ_G0028826
protein coding gene Chr5:89755656-89967914 (-)
CBA/J MGP_CBAJ_G0029385
protein coding gene Chr5:97557173-97790621 (-)
DBA/2J MGP_DBA2J_G0029530
protein coding gene Chr5:87192145-87398926 (-)
FVB/NJ MGP_FVBNJ_G0029489
protein coding gene Chr5:86100280-86305482 (-)
LP/J MGP_LPJ_G0029618
protein coding gene Chr5:91094192-91318277 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029518
protein coding gene Chr5:102572024-102785581 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030181
protein coding gene Chr5:89509072-89716634 (-)
PWK/PhJ MGP_PWKPhJ_G0028545
protein coding gene Chr5:86263070-86478295 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028380
protein coding gene Chr5:88921376-89153613 (-)
WSB/EiJ MGP_WSBEiJ_G0028905
protein coding gene Chr5:89919669-90134888 (-)



Homology
more
  • Human Ortholog
    ADAMTS3, ADAM metallopeptidase with thrombospondin type 1 motif 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADAMTS3, ADAM metallopeptidase with thrombospondin type 1 motif 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADAMTS-4, HKLLS3
  • Links
    NCBI Gene ID: 9508
    neXtProt AC: NX_O15072
    UniProt: O15072

  • Chr Location
    4q13.3; chr4:72280969-72568799 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit lethality after E15, edema, absent lymphatic vessels, liver degeneration, and abnormal placenta labyrinth morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043635 Ensembl Gene Model | MGI Sequence Detail 206248 C57BL/6J ±  kb
    transcript ENSMUST00000163159 Ensembl | MGI Sequence Detail 3937 Not Applicable  
    polypeptide ENSMUSP00000132219 Ensembl | MGI Sequence Detail 1204 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 28
      Primer pair 1

      Microarray probesets 16
    Other
    Accession IDs
    less
    MGI:1915676
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:261316 Perez-Garcia V, et al., Placentation defects are highly prevalent in embryonic lethal mouse mutants. Nature. 2018 Mar 22;555(7697):463-468

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory