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Olfm2 Gene Detail
Summary
  • Symbol
    Olfm2
  • Name
    olfactomedin 2
  • Synonyms
    A030009A06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045350
    NCBI Gene: 244723
  • Gene Overview
    MyGene.info: OLFM2
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr9:20667691-20746307 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.60 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045350
protein coding gene Chr9:20667690-20746349 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034425
protein coding gene Chr9:17815692-17878490 (-)
A/J MGP_AJ_G0034403
protein coding gene Chr9:17531173-17594260 (-)
AKR/J MGP_AKRJ_G0034330
protein coding gene Chr9:17851550-17912325 (-)
BALB/cJ MGP_BALBcJ_G0034394
protein coding gene Chr9:17435001-17495881 (-)
C3H/HeJ MGP_C3HHeJ_G0034106
protein coding gene Chr9:18161701-18228062 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034915
protein coding gene Chr9:18546039-18608391 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031845
protein coding gene Chr9:16666863-16726555 (-)
CAST/EiJ MGP_CASTEiJ_G0033429
protein coding gene Chr9:17976605-18040866 (-)
CBA/J MGP_CBAJ_G0034079
protein coding gene Chr9:19249401-19317932 (-)
DBA/2J MGP_DBA2J_G0034238
protein coding gene Chr9:17526966-17588701 (-)
FVB/NJ MGP_FVBNJ_G0034181
protein coding gene Chr9:17027246-17088557 (-)
LP/J MGP_LPJ_G0034323
protein coding gene Chr9:17999128-18064034 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034224
protein coding gene Chr9:20887087-20948826 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034935
protein coding gene Chr9:17795131-17864295 (-)
PWK/PhJ MGP_PWKPhJ_G0033135
protein coding gene Chr9:17488638-17550935 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032969
protein coding gene Chr9:17837787-17900109 (-)
WSB/EiJ MGP_WSBEiJ_G0033544
protein coding gene Chr9:17526829-17593089 (-)



Homology
more
  • Human Ortholog
    OLFM2, olfactomedin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    OLFM2, olfactomedin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NOE2, NOELIN2, NOELIN2_V1, OlfC
  • Links
    NCBI Gene ID: 93145
    neXtProt AC: NX_O95897
    UniProt: O95897

  • Chr Location
    19p13.2; chr19:9853718-9936552 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit moderate locomotor and anxiety-related behavioral abnormalities, altered visual evoked potential, and reduced compactness of myelin sheaths in the optic nerve.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 244723 NCBI Gene Model | MGI Sequence Detail 78617 C57BL/6J ±  kb
    transcript NM_001357635 RefSeq | MGI Sequence Detail 2077 C57BL/6  
    polypeptide Q8BM13 UniProt | EBI | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 11
      Primer pair 3

      Microarray probesets 2
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 5
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:263671 Shi N, et al., Olfactomedin 2 Regulates Smooth Muscle Phenotypic Modulation and Vascular Remodeling Through Mediating Runt-Related Transcription Factor 2 Binding to Serum Response Factor. Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):446-454

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory