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Usp44 Gene Detail
Summary
  • Symbol
    Usp44
  • Name
    ubiquitin specific peptidase 44
  • Synonyms
    E430004F17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045318
    NCBI Gene: 327799
  • Gene Overview
    MyGene.info: USP44
Location & Maps
more
  • Sequence Map
    Chr10:93831555-93848524 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16970 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 48.67 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    USP44, ubiquitin specific peptidase 44
  • Vertebrate Orthologs
    9
  • Human Ortholog
    USP44, ubiquitin specific peptidase 44
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 84101
    neXtProt AC: NX_Q9H0E7

  • Chr Location
    12q22; chr12:95516560-95551529 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 12961
    1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: USP44
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    3 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    13
  • Targeted
    8
  • Transposon induced
    1
  • Genomic Mutations
    2 involving Usp44
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit chromosomal instability, aneuploidy and increased tumor incidence.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020020 Ensembl Gene Model | MGI Sequence Detail 16970 C57BL/6J ±  kb
transcript ENSMUST00000095333 Ensembl | MGI Sequence Detail 2932 Not Applicable  
polypeptide ENSMUSP00000092975 Ensembl | MGI Sequence Detail 505 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    404 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
    IPR013083 Zinc finger, RING/FYVE/PHD-type
    IPR001607 Zinc finger, UBP-type
Molecular
Reagents
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  • All nucleic 4
    cDNA 4

    Microarray probesets 1
References
more
  • Summaries
    All 24
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:193965 Zhang Y, et al., USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. J Clin Invest. 2012 Dec 3;122(12):4362-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory