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Bpi
Gene Detail
 Symbol
Name
ID
Bpi
bactericidal permeablility increasing protein
MGI:3045315
Synonyms 9230105K17Rik, Bpifd1
Feature Type protein coding gene
Genetic Map
Chromosome 2
78.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:158258094-158284531 bp, + strand
From VEGA annotation of GRCm38

  26438 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37519  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: phospho/glycolipid-binding protein, BPI/LBP type
Gene Tree: Bpi

Human
homologs
Human Homolog BPI, bactericidal/permeability-increasing protein
NCBI Gene ID 671
neXtProt AC  NX_P17213
Human Synonyms  BPIFD1, rBPI
Human Chr (Location)  20q11.23; chr20:38304150-38337505 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(5) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Bpi interacts with 50 markers (Mir22, Mir23a, Mir30c-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process defense response to bacterium, immune response, ...
Component cytoplasm, extracellular region, ...
Function lipid binding, lipopolysaccharide binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(5)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000015932 (Evidence)
Ensembl Gene ModelENSMUSG00000052922 (Evidence)
Entrez Gene329547 (Evidence)
UniGene260883
DFCITC1591579, TC1595180
DoTSDT.91579583
Consensus CDS ProjectCCDS16987.1
International Mouse Knockout Project StatusBpi
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015932 VEGA Gene Model | MGI Sequence Detail 26438 C57BL/6J ±  kb
transcript OTTMUST00000037849 VEGA | MGI Sequence Detail 1926 Not Applicable 
polypeptide OTTMUSP00000016993 VEGA | MGI Sequence Detail 486 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(187 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain
InterPro IPR001124 Lipid-binding serum glycoprotein, C-terminal
InterPro IPR017942 Lipid-binding serum glycoprotein, N-terminal
Protein Ontology PR:000004794 bactericidal permeability-increasing protein
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:174122 Bingle CD, et al., Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. Biochem Soc Trans. 2011 Aug 1;39(4):977-83
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory