Bpi MGI Mouse Gene Detail - MGI:3045315 - bactericidal permeablility increasing protein

Symbol

Bpi
Name

bactericidal permeablility increasing protein
Synonyms

9230105K17Rik, Bpifd1

Feature Type

protein coding gene
IDs

MGI:3045315
NCBI Gene: 329547
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:158100014-158126451 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 78.72 cM
Mapping Data

1 experiment

SNPs within 2kb

952 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045315	protein coding gene	Chr2:158099983-158126453 (+)
129S1/SvImJ	ENSMUSG00200015569	protein coding gene	Chr2:154962637-154988934 (+)
A/J	ENSMUSG00195021368	protein coding gene	Chr2:155331595-155358072 (+)
AKR/J	ENSMUSG00220012979	protein coding gene	Chr2:154660543-154686985 (+)
BALB/cJ	ENSMUSG00180041945	protein coding gene	Chr2:154784755-154811189 (+)
C3H/HeJ	ENSMUSG00175049827	protein coding gene	Chr2:155534913-155561357 (+)
C57BL/6NJ	ENSMUSG00215034922	protein coding gene	Chr2:154949623-154976074 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024585	protein coding gene	Chr2:150217277-150244857 (+)
CAST/EiJ	ENSTCUG00005043953	protein coding gene	Chr2:153932944-153959419 (+)
CBA/J	ENSMUSG00210015291	protein coding gene	Chr2:155466023-155492460 (+)
DBA/2J	ENSMUSG00185046752	protein coding gene	Chr2:155184904-155211205 (+)
FVB/NJ	ENSMUSG00205031631	protein coding gene	Chr2:154217105-154243555 (+)
JF1/MsJ	ENSUMUG00000010014	protein coding gene	Chr2:154835554-154862079 (+)
LP/J	ENSMUSG00230045007	protein coding gene	Chr2:156760153-156786462 (+)
NOD/ShiLtJ	ENSMUSG00190039992	protein coding gene	Chr2:154860010-154886450 (+)
NZO/HlLtJ	ENSMUSG00225049549	protein coding gene	Chr2:164775626-164801956 (+)
PWK/PhJ	ENSLUMG00010046640	protein coding gene	Chr2:154777794-154804209 (+)
SPRET/EiJ	ENSMSPG00010032975	protein coding gene	Chr2:157535018-157561731 (+)
WSB/EiJ	ENSIUOG00005043928	protein coding gene	Chr2:154552831-154586748 (+)

Human Ortholog

BPI, bactericidal permeability increasing protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BPI, bactericidal permeability increasing protein
Synonyms

BPIFD1, rBPI
Links

HGNC:1095

NCBI Gene ID: 671

UniProt: P17213
Chr Location

20q11.23; chr20:38260141-38337505 (+) GRCh38

MGI Vertebrate Homology

Bpi stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BPI
Protein SuperFamily

Lipid_binding_protein
Gene Tree

Bpi

Diseases

1 with human BPI associations

				Human Disease	Mouse Models
				Crohn's disease IDs Crohn's disease DOID:8778 DOID:8784 DOID:8855 DOID:8942 EFO:0000384 ICD10CM:K50.1 ICD9CM:555.1 MESH:D003424 NCI:C37262 UMLS_CUI:C0156147

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

5
Gene trapped

5
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display increased susceptibility to induced colitis and impaired IL22 induction.

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All GO Annotations

28
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

6
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bpi.4

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All Sequences

43
RefSeq

8
UniProt

1
CCDS

CCDS16987.1, CCDS89574.1

Ensembl

ENSMUSG00000052922 (Evidence)
NCBI Gene

329547

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052922	Ensembl Gene Model \| MGI Sequence Detail	26438	C57BL/6J	± kb
transcript	ENSMUST00000065039	Ensembl \| MGI Sequence Detail	1926	Not Applicable
polypeptide	ENSMUSP00000067837	Ensembl \| MGI Sequence Detail	486	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004794 bactericidal permeability-increasing protein

(term hierarchy)
InterPro Domains

IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain superfamily

IPR032942 BPI/LBP/Plunc family

IPR030675 Lipid binding protein BPI/LBP

IPR001124 Lipid-binding serum glycoprotein, C-terminal

IPR017942 Lipid-binding serum glycoprotein, N-terminal
GlyGen

Q67E05 2 sites

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All nucleic 6

cDNA 6

Microarray probesets 1

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 15
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:346703 Bulow S, et al., Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response. Cell Rep. 2024 Mar 26;43(3):113929

TSS for Bpi:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21302	Chr2:158099985-158100029 (+)	-7 bp
Tssr21303	Chr2:158100123-158100129 (+)	112 bp
Tssr727	Chr2:158100138-158100139 (+)	125 bp
Tssr21304	Chr2:158100145-158100152 (+)	135 bp
Tssr21305	Chr2:158100157-158100166 (+)	148 bp
Tssr21306	Chr2:158100180-158100196 (+)	174 bp
Tssr21307	Chr2:158104623-158104628 (+)	4,612 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24