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Bpi Gene Detail
Summary
  • Symbol
    Bpi
  • Name
    bactericidal permeablility increasing protein
  • Synonyms
    9230105K17Rik, Bpifd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045315
    NCBI Gene: 329547
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:158258094-158284531 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 78.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    183 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045315
protein coding gene Chr2:158258063-158284533 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026791
protein coding gene Chr2:163322449-163353839 (+)
A/J MGP_AJ_G0026757
protein coding gene Chr2:156779026-156805663 (+)
AKR/J MGP_AKRJ_G0026728
protein coding gene Chr2:161403775-161430077 (+)
BALB/cJ MGP_BALBcJ_G0026766
protein coding gene Chr2:157081449-157108489 (+)
C3H/HeJ MGP_C3HHeJ_G0026508
protein coding gene Chr2:161714202-161749104 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027215
protein coding gene Chr2:168181889-168211677 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024585
protein coding gene Chr2:150217277-150244857 (+)
CAST/EiJ MGP_CASTEiJ_G0025970
protein coding gene Chr2:162076922-162107708 (+)
CBA/J MGP_CBAJ_G0026485
protein coding gene Chr2:174215448-174255418 (+)
DBA/2J MGP_DBA2J_G0026623
protein coding gene Chr2:155951334-155979665 (+)
FVB/NJ MGP_FVBNJ_G0026590
protein coding gene Chr2:154357852-154386937 (+)
LP/J MGP_LPJ_G0026726
protein coding gene Chr2:163412611-163444542 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026611
protein coding gene Chr2:178020061-178052137 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027271
protein coding gene Chr2:161218983-161254654 (+)
PWK/PhJ MGP_PWKPhJ_G0025704
protein coding gene Chr2:155472027-155506389 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025507
protein coding gene Chr2:160139681-160169269 (+)
WSB/EiJ MGP_WSBEiJ_G0026040
protein coding gene Chr2:162116272-162144262 (+)



Homology
more
  • Human Ortholog
    BPI, bactericidal permeability increasing protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BPI, bactericidal permeability increasing protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BPIFD1, rBPI
  • Links
    NCBI Gene ID: 671
    neXtProt AC: NX_P17213
    UniProt: P17213

  • Chr Location
    20q11.23; chr20:38304150-38337503 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052922 Ensembl Gene Model | MGI Sequence Detail 26438 C57BL/6J ±  kb
transcript ENSMUST00000065039 Ensembl | MGI Sequence Detail 1926 Not Applicable  
polypeptide ENSMUSP00000067837 Ensembl | MGI Sequence Detail 486 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004794 bactericidal permeability-increasing protein
  • InterPro Domains
    IPR030181 Bactericidal permeability-increasing protein
    IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain superfamily
    IPR032942 BPI/LBP/Plunc family
    IPR030675 Lipid binding protein BPI/LBP
    IPR001124 Lipid-binding serum glycoprotein, C-terminal
    IPR017942 Lipid-binding serum glycoprotein, N-terminal
Molecular
Reagents
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  • All nucleic 6
    cDNA 6

    Microarray probesets 1
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory