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Synb Gene Detail
Summary
  • Symbol
    Synb
  • Name
    syncytin b
  • Synonyms
    D930020E02Rik, syncytin-B
Location &
Maps
more
  • Sequence Map
    Chr14:69526793-69531748 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.04 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    51 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045308
 protein coding gene Chr14:69526793-69549857 (-)
129S1/SvImJ no annotation
A/J ENSMUSG00195013381
 protein coding gene Chr14:58317875-58322831 (-)
AKR/J ENSMUSG00220029473
 protein coding gene Chr14:57653638-57658593 (-)
BALB/cJ ENSMUSG00180034638
 protein coding gene Chr14:57926467-57931422 (-)
C3H/HeJ ENSMUSG00175031964
 protein coding gene Chr14:59687054-59692009 (-)
C57BL/6NJ ENSMUSG00215011798
 protein coding gene Chr14:57863195-57868150 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019462
 protein coding gene Chr14:60384294-60389029 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210039084
 protein coding gene Chr14:58302901-58307856 (-)
DBA/2J ENSMUSG00185023329
 protein coding gene Chr14:63472470-63477425 (-)
FVB/NJ ENSMUSG00205032097
 protein coding gene Chr14:57812361-57817316 (-)
JF1/MsJ no annotation
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190030402
 protein coding gene Chr14:58097692-58102647 (-)
NZO/HlLtJ ENSMUSG00225039736
 protein coding gene Chr14:65824968-65829923 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ERVFRD-1, endogenous retrovirus group FRD member 1, envelope
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERVFRD-1, endogenous retrovirus group FRD member 1, envelope
  • Synonyms
    envFRD, ERVFRDE1, GLLL6191, HERV-FRD, HERV-W/FRD, UNQ6191
  • Links
    NCBI Gene ID: 405754
    UniProt: P60508

  • Chr Location
    6p24.2; chr6:11102324-11111845 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    3 images
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired syncytiotrophoblast layer II formation, growth retardation and partial preweaning lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    647
  • Tissues
    19
  • cDNA Data
    4
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047977 Ensembl Gene Model | MGI Sequence Detail 4956 C57BL/6J ±  kb
    transcript ENSMUST00000059362 Ensembl | MGI Sequence Detail 4055 Not Applicable  
    polypeptide ENSMUSP00000061107 Ensembl | MGI Sequence Detail 618 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR018154 TLV/ENV coat polyprotein
    • GlyGen
      Q8BI41 4 sites
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 5
      Primer pair 4
      Other 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 31
      Gene Ontology 7
      Phenotypes 8
    • Earliest
      J:96249 Dupressoir A, et al., Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae. Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):725-30
    • Latest
      J:376309 Viscomi MP, et al., Embryonic and placental factors are linked with the development of autism-like behaviors in the BTBR mouse model. Neuroscience. 2025 Dec 5;593:18-28
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory