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Exd1 Gene Detail
Summary
  • Symbol
    Exd1
  • Name
    exonuclease 3'-5' domain containing 1
  • Synonyms
    4932702D22Rik, Exdl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045306
    NCBI Gene: 241624
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:119346986-119378108 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    903 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045306
 protein coding gene Chr2:119346986-119378108 (-)
129S1/SvImJ ENSMUSG00200045887
 protein coding gene Chr2:116284693-116315608 (-)
A/J ENSMUSG00195022415
 protein coding gene Chr2:116338656-116369598 (-)
AKR/J ENSMUSG00220036550
 protein coding gene Chr2:116250177-116281065 (-)
BALB/cJ ENSMUSG00180038387
 protein coding gene Chr2:116139019-116169961 (-)
C3H/HeJ ENSMUSG00175024509
 protein coding gene Chr2:116600254-116634555 (-)
C57BL/6NJ ENSMUSG00215017203
 protein coding gene Chr2:116264365-116295490 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024145
 protein coding gene Chr2:112350918-112382663 (-)
CAST/EiJ ENSTCUG00005015631
 protein coding gene Chr2:115536266-115567343 (-)
CBA/J ENSMUSG00210006908
 protein coding gene Chr2:116441232-116475537 (-)
DBA/2J ENSMUSG00185041218
 protein coding gene Chr2:116136762-116167699 (-)
FVB/NJ ENSMUSG00205036228
 protein coding gene Chr2:115350965-115381855 (-)
JF1/MsJ ENSUMUG00000018933
 protein coding gene Chr2:116005899-116036967 (-)
LP/J ENSMUSG00230016280
 protein coding gene Chr2:117944379-117975296 (-)
NOD/ShiLtJ ENSMUSG00190044139
 protein coding gene Chr2:116369473-116403782 (-)
NZO/HlLtJ ENSMUSG00225003846
 protein coding gene Chr2:125847797-125882277 (-)
PWK/PhJ ENSLUMG00010046320
 protein coding gene Chr2:115913879-115945048 (-)
SPRET/EiJ ENSMSPG00010036272
 protein coding gene Chr2:118320131-118347658 (-)
WSB/EiJ ENSIUOG00005024180
 protein coding gene Chr2:116100640-116131653 (-)



Homology
more
  • Human Ortholog
    EXD1, exonuclease 3'-5' domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EXD1, exonuclease 3'-5' domain containing 1
  • Synonyms
    EXDL1
  • Links
    NCBI Gene ID: 161829
    UniProt: Q8NHP7

  • Chr Location
    15q15.1; chr15:41182725-41230757 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are fertile and viable, but exhibit defective biogenesis of antisense piRNAs and activation of transposons in male germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    1
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 241624 NCBI Gene Model | MGI Sequence Detail 31123 C57BL/6J ±  kb
    transcript NM_172857 RefSeq | MGI Sequence Detail 6042 C57BL/6  
    polypeptide Q8CDF7 UniProt | EBI | MGI Sequence Detail 570 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6
      Antibodies 2

      Microarray probesets 2
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory