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Fan1 Gene Detail
Summary
  • Symbol
    Fan1
  • Name
    FANCD2/FANCI-associated nuclease 1
  • Synonyms
    6030441H18Rik, Mtmr15
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045266
    NCBI Gene: 330554
  • Gene Overview
    MyGene.info: FAN1
Location & Maps
more
  • Sequence Map
    Chr7:64346758-64374095 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27338 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 34.64 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    FAN1, FANCD2/FANCI-associated nuclease 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FAN1, FANCD2/FANCI-associated nuclease 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hFAN1, KIAA1018, KMIN, MTMR15
  • Links
    NCBI Gene ID: 22909
    neXtProt AC: NX_Q9Y2M0

  • Chr Location
    15q13.3; chr15:30903852-30943108 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 45598
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FAN1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human FAN1 associations

Human Disease Mouse Models
       Interstitial Nephritis, Karyomegalic; KMIN   OMIM: 614817
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotype references
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Fan1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026085 VEGA Gene Model | MGI Sequence Detail 27338 C57BL/6J ±  kb
transcript OTTMUST00000110531 VEGA | MGI Sequence Detail 3460 Not Applicable  
polypeptide OTTMUSP00000061671 VEGA | MGI Sequence Detail 1020 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    390 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 25
    Gene Ontology 5
    Phenotypes 16
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:217316 Pennell S, et al., FAN1 activity on asymmetric repair intermediates is mediated by an atypical monomeric virus-type replication-repair nuclease domain. Cell Rep. 2014 Jul 10;8(1):84-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory