Sppl2c MGI Mouse Gene Detail - MGI:3045264 - signal peptide peptidase 2C

Symbol

Sppl2c
Name

signal peptide peptidase 2C
Synonyms

4933407P14Rik

Feature Type

protein coding gene
IDs

MGI:3045264
NCBI Gene: 237958
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:104077153-104081989 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 67.79 cM
Mapping Data

1 experiment

SNPs within 2kb

230 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3045264	protein coding gene	Chr11:104077153-104081992 (+)
129S1/SvImJ	ENSMUSG00200052768	protein coding gene	Chr11:101364357-101369189 (+)
A/J	ENSMUSG00195047445	protein coding gene	Chr11:101069288-101074097 (+)
AKR/J	ENSMUSG00220048999	protein coding gene	Chr11:101282991-101287847 (+)
BALB/cJ	ENSMUSG00180047202	protein coding gene	Chr11:101397629-101402473 (+)
C3H/HeJ	ENSMUSG00175048063	protein coding gene	Chr11:101337963-101342795 (+)
C57BL/6NJ	ENSMUSG00215050416	protein coding gene	Chr11:100899991-100904827 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017290	protein coding gene	Chr11:100166286-100171072 (+)
CAST/EiJ	ENSTCUG00005046819	protein coding gene	Chr11:100833611-100838427 (+)
CBA/J	ENSMUSG00210052103	protein coding gene	Chr11:101039791-101044608 (+)
DBA/2J	ENSMUSG00185046768	protein coding gene	Chr11:101387782-101392614 (+)
FVB/NJ	ENSMUSG00205040500	protein coding gene	Chr11:101211754-101216598 (+)
JF1/MsJ	ENSUMUG00000010711	protein coding gene	Chr11:101656237-101661078 (+)
LP/J	ENSMUSG00230029915	protein coding gene	Chr11:102440102-102444938 (+)
NOD/ShiLtJ	ENSMUSG00190044178	protein coding gene	Chr11:101405695-101410539 (+)
NZO/HlLtJ	ENSMUSG00225051476	protein coding gene	Chr11:104465799-104470655 (+)
PWK/PhJ	ENSLUMG00010038591	protein coding gene	Chr11:101188047-101192875 (+)
SPRET/EiJ	ENSMSPG00010050091	protein coding gene	Chr11:101665612-101670262 (+)
WSB/EiJ	ENSIUOG00005049145	protein coding gene	Chr11:101179780-101184615 (+)

Human Ortholog

SPPL2C, signal peptide peptidase like 2C

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPPL2C, signal peptide peptidase like 2C
Synonyms

IMP5
Links

HGNC:28902

NCBI Gene ID: 162540

UniProt: Q8IUH8
Chr Location

17q21.31; chr17:45844881-45847067 (+) GRCh38

MGI Vertebrate Homology

Sppl2c stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPPL2C
Gene Tree

Sppl2c

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
1 phenotype from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Targeted

7
Genomic Mutations

5 involving Sppl2c
Incidental Mutations

APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased testis weight, decreased number of elongated spermatids, asthenozoospermia, and decreased litter size in matings of male and female homozygotes.

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All GO Annotations

35
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

8

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

4
UniProt

1
CCDS

CCDS36351.1, CCDS36352.1

Ensembl

ENSMUSG00000049506 (Evidence)
NCBI Gene

237958

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049506	Ensembl Gene Model \| MGI Sequence Detail	4837	C57BL/6J	± kb
transcript	ENSMUST00000107000	Ensembl \| MGI Sequence Detail	2225	Not Applicable
polypeptide	ENSMUSP00000102613	Ensembl \| MGI Sequence Detail	690	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015565 signal peptide peptidase-like 2C

(term hierarchy)
EC

3.4.23.-
InterPro Domains

IPR003137 PA domain

IPR007369 Peptidase A22B, signal peptide peptidase

IPR006639 Presenilin/signal peptide peptidase
GlyGen

A2A6C4 1 site

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All nucleic 8

cDNA 8

Microarray probesets 1

Summaries

All 35

Gene Ontology 10

Phenotypes 10
Earliest

J:162220 Magdaleno S, et al., BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
Latest

J:390071 Angera IJ, et al., Macrocyclic beta-arch peptides that mimic the structure and function of disease-associated tau folds. Nat Chem. 2025 Jun;17(6):865-874

TSS for Sppl2c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105371	Chr11:104077171-104077184 (+)	25 bp
Tssr105372	Chr11:104081826-104081830 (+)	4,675 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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