About   Help   FAQ
C1qtnf9 Gene Detail
Summary
  • Symbol
    C1qtnf9
  • Name
    C1q and tumor necrosis factor related protein 9
  • Synonyms
    9130217G22Rik, CTRP9
  • Feature Type
    protein coding gene
  • IDs
    MGI:3045252
    NCBI Gene: 239126
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:60768134-60780869 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 31.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    29 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3045252
protein coding gene Chr14:60768134-60780869 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021434
protein coding gene Chr14:55114145-55127210 (+)
A/J MGP_AJ_G0021393
protein coding gene Chr14:53923824-53936519 (+)
AKR/J MGP_AKRJ_G0021368
protein coding gene Chr14:55843265-55858386 (+)
BALB/cJ MGP_BALBcJ_G0021398
protein coding gene Chr14:53881187-53893799 (+)
C3H/HeJ MGP_C3HHeJ_G0021176
protein coding gene Chr14:55503464-55516161 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021837
protein coding gene Chr14:57830799-57848114 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019377
protein coding gene Chr14:51943137-51956873 (+)
CAST/EiJ MGP_CASTEiJ_G0020692
protein coding gene Chr14:51891777-51905392 (+)
CBA/J MGP_CBAJ_G0021143
protein coding gene Chr14:59475483-59493628 (+)
DBA/2J MGP_DBA2J_G0021266
protein coding gene Chr14:53606143-53619021 (+)
FVB/NJ MGP_FVBNJ_G0021244
protein coding gene Chr14:53014080-53026640 (+)
LP/J MGP_LPJ_G0021340
protein coding gene Chr14:56164632-56179719 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021273
protein coding gene Chr14:58823788-58837019 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021860
protein coding gene Chr14:54995511-55009154 (+)
PWK/PhJ MGP_PWKPhJ_G0020436
protein coding gene Chr14:50260947-50274969 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020269
protein coding gene Chr14:50945263-50960679 (+)
WSB/EiJ MGP_WSBEiJ_G0020745
protein coding gene Chr14:55311060-55325103 (+)



Homology
more
  • Human Ortholog
    C1QTNF9, C1q and TNF related 9
  • Vertebrate Orthologs
    7
  • Human Ortholog
    C1QTNF9, C1q and TNF related 9
    Orthology source: HGNC
  • Synonyms
    AQL1, C1QTNF9A, CTRP9
  • Links
    NCBI Gene ID: 338872
    neXtProt AC: NX_P0C862
    UniProt: P0C862

  • Chr Location
    13q12.12; chr13:24307166-24322531 (+)  GRCh38.p7

  • Human Ortholog
    C1QTNF9B, C1q and TNF related 9B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CTRP9B
  • Links
    NCBI Gene ID: 387911
    neXtProt AC: NX_B2RNN3
    UniProt: B2RNN3

  • Chr Location
    13q12.12; chr13:23891099-23898541 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased caloric intake, increased percent body fat/body weight, obesity, insulin resistance, and hepatic steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 239126 NCBI Gene Model | MGI Sequence Detail 12736 C57BL/6J ±  kb
    transcript NM_183175 RefSeq | MGI Sequence Detail 1903 C57BL/6  
    polypeptide Q4ZJN1 UniProt | EBI | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR001073 C1q domain
      IPR008160 Collagen triple helix repeat
      IPR008983 Tumour necrosis factor-like domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 9
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 12
    • Earliest
      J:146036 Wong GW, et al., Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. FASEB J. 2009 Jan;23(1):241-58
    • Latest
      J:266935 Yan W, et al., C1q/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways. Circulation. 2017 Nov 28;136(22):2162-2177

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory