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Arhgef15
Gene Detail
Symbol

Name
ID
Arhgef15
Rho guanine nucleotide exchange factor (GEF) 15
MGI:3045246
Synonyms
D530030K12Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr11:68943157-68957480 bp, - strand
From VEGA annotation of GRCm38

  14324 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:18345  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Arhgef15

Human
homologs
Human Homolog ARHGEF15, Rho guanine nucleotide exchange factor (GEF) 15
NCBI Gene ID 22899
neXtProt AC  NX_O94989
Human Synonyms  ARGEF15, E5, Ephexin5, Vsm-RhoGEF
Human Chr (Location)  17p13.1; chr17:8310238-8322516 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock out allele exhibit increased excitatory synapse formation. Mice homozygous for a knock-out allele exhibit delayed radial growth, sparse vasculature and empty baselment membrane sleeves in the retina.
 
Interactions
Arhgef15 interacts with 275 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (23)    Tissues (1)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 23
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005952 (Evidence)
Ensembl Gene ModelENSMUSG00000052921 (Evidence)
Entrez Gene442801 (Evidence)
UniGene376147
DFCITC1590260, TC1582535
DoTSDT.101290341, DT.87068301
NIA Mouse Gene IndexU032949
Consensus CDS ProjectCCDS24873.1
International Mouse Knockout Project StatusArhgef15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005952 VEGA Gene Model | MGI Sequence Detail 14324 C57BL/6J ±  kb
transcript OTTMUST00000013260 VEGA | MGI Sequence Detail 4372 Not Applicable 
polypeptide OTTMUSP00000006147 VEGA | MGI Sequence Detail 849 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(16) UniProt(3)
Polymorphisms
SNPs within 2kb(179 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000219 Dbl homology (DH) domain
Protein Ontology PR:000004250 rho guanine nucleotide exchange factor 15
References
(Earliest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
(Latest) J:201159 Zhou P, et al., Interrogating translational efficiency and lineage-specific transcriptomes using ribosome affinity purification. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15395-400
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory