Arhgef15
Gene Detail

Symbol Name ID

Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 MGI:3045246

Synonyms

D530030K12Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.21 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr11:68943157-68957480 bp, - strand From VEGA annotation of GRCm38   14324 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:18345  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Arhgef15

Human homologs

Human Homolog		ARHGEF15, Rho guanine nucleotide exchange factor (GEF) 15
NCBI Gene ID		22899
neXtProt AC		NX_O94989
Human Synonyms		ARGEF15, E5, Ephexin5, Vsm-RhoGEF
Human Chr (Location)		17p13.1; chr17:8213556-8225834 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(7) Gene trapped(2)
 

Mice homozygous for a knock out allele exhibit increased excitatory synapse formation. Mice homozygous for a knock-out allele exhibit delayed radial growth, sparse vasculature and empty baselment membrane sleeves in the retina.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	negative regulation of synapse maturation, regulation of catalytic activity, ...
Component	cell projection, dendrite
Function	GTPase activator activity, guanyl-nucleotide exchange factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (23)    Tissues (1)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	23

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(20)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005952 (Evidence)
Ensembl Gene Model	ENSMUSG00000052921 (Evidence)
Entrez Gene	442801 (Evidence)
UniGene	376147
DFCI	TC1582535, TC1590260
DoTS	DT.101290341, DT.87068301
NIA Mouse Gene Index	U032949
Consensus CDS Project	CCDS24873.1
International Mouse Knockout Project Status	Arhgef15

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005952	VEGA Gene Model | MGI Sequence Detail	14324	C57BL/6J
transcript	OTTMUST00000013260	VEGA | MGI Sequence Detail	4372	Not Applicable
polypeptide	OTTMUSP00000006147	VEGA | MGI Sequence Detail	849	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(74 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000219	Dbl homology (DH) domain
Protein Ontology	PR:000004250	rho guanine nucleotide exchange factor 15

References

(Earliest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
(Latest) J:191977 Kusuhara S, et al., Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells. PLoS One. 2012;7(9):e45858
All references(33)