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Wipf3 Gene Detail
Summary
  • Symbol
    Wipf3
  • Name
    WAS/WASL interacting protein family, member 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3044681
    NCBI Gene: 330319
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:54429603-54503768 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 26.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    358 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3044681
protein coding gene Chr6:54429216-54503768 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030760
protein coding gene Chr6:53781373-53858894 (+)
A/J MGP_AJ_G0030729
protein coding gene Chr6:51290948-51366421 (+)
AKR/J MGP_AKRJ_G0030656
protein coding gene Chr6:53032643-53109221 (+)
BALB/cJ MGP_BALBcJ_G0030741
protein coding gene Chr6:51642649-51717012 (+)
C3H/HeJ MGP_C3HHeJ_G0030454
protein coding gene Chr6:53048116-53127500 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031196
protein coding gene Chr6:54982164-55059615 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028402
protein coding gene Chr6:48896941-48974297 (+)
CAST/EiJ MGP_CASTEiJ_G0029857
protein coding gene Chr6:52894986-52977634 (+)
CBA/J MGP_CBAJ_G0030428
protein coding gene Chr6:57242199-57324380 (+)
DBA/2J MGP_DBA2J_G0030578
protein coding gene Chr6:51192688-51266776 (+)
FVB/NJ MGP_FVBNJ_G0030530
protein coding gene Chr6:50777762-50852677 (+)
LP/J MGP_LPJ_G0030663
protein coding gene Chr6:53729415-53804860 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030564
protein coding gene Chr6:59773621-59862014 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031226
protein coding gene Chr6:52979784-53059730 (+)
PWK/PhJ MGP_PWKPhJ_G0029570
protein coding gene Chr6:50843714-50918631 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029404
protein coding gene Chr6:52354402-52434772 (+)
WSB/EiJ MGP_WSBEiJ_G0029934
protein coding gene Chr6:53008413-53084404 (+)



Homology
more
  • Human Ortholog
    WIPF3, WAS/WASL interacting protein family member 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    WIPF3, WAS/WASL interacting protein family member 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CR16
  • Links
    NCBI Gene ID: 644150
    neXtProt AC: NX_A6NGB9
    UniProt: A6NGB9

  • Chr Location
    7p14.3; chr7:29806554-29917066 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display impaired spermatogenesis, abnormal sperm head morphology, and significantly reduced male fertility. Female fertility is not affected.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000086040 Ensembl Gene Model | MGI Sequence Detail 74166 C57BL/6J ±  kb
transcript ENSMUST00000172046 Ensembl | MGI Sequence Detail 4204 Not Applicable  
polypeptide ENSMUSP00000132138 Ensembl | MGI Sequence Detail 483 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 4
    cDNA 4

    Microarray probesets 1
Other
Accession IDs
less
MGI:2141631
References
more
  • Summaries
    All 23
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory