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Wipf3
Gene Detail
Symbol

Name
ID
Wipf3
WAS/WASL interacting protein family, member 3
MGI:3044681
Feature Type
protein coding gene
Genetic Map
Chromosome 6
26.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:54429603-54503765 bp, + strand
From VEGA annotation of GRCm38

  74163 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113391  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: WIPF3
Gene Tree: Wipf3

Human
homologs
WIPF3, WAS/WASL interacting protein family, member 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 644150
neXtProt AC: NX_A6NGB9

Human Synonyms: CR16

Human Chr (Location): 7p14.3; chr7:29806554-29917066 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display impaired spermatogenesis, abnormal sperm head morphology, and significantly reduced male fertility. Female fertility is not affected.
 
Interactions
Wipf3 interacts with 350 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cell differentiation, multicellular organismal development, ...
Component cytoplasm
Function actin binding, SH3 domain binding
External Resources: FuncBase
Expression
cDNA source data(4)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(4) cDNA(4)
Microarray probesets(1)
Other database
links
VEGA Gene Model OTTMUSG00000033222 (Evidence)
Ensembl Gene Model ENSMUSG00000086040 (Evidence)
Entrez Gene 330319 (Evidence)
DFCI TC1602425, TC1689487, TC1612535
DoTS DT.101363264, DT.103578110, DT.55220464, DT.50315922
NIA Mouse Gene Index U006891
Consensus CDS Project CCDS51779.1, CCDS51780.1
International Mouse Phenotyping Consortium Status Wipf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033222 VEGA Gene Model | MGI Sequence Detail 74163 C57BL/6J ±  kb
transcript OTTMUST00000083237 VEGA | MGI Sequence Detail 4516 Not Applicable 
polypeptide OTTMUSP00000044691 VEGA | MGI Sequence Detail 483 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(358 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003124 WH2 domain
Protein Ontology PR:000017424 WAS/WASL-interacting protein family member 3
References
(Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(27)
Other
accession IDs
MGI:2141631

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory