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Tgm6
Gene Detail
Symbol

Name
ID
Tgm6
transglutaminase 6
MGI:3044321
Synonyms
TGM3L
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr2:130112416-130154232 bp, + strand
From VEGA annotation of GRCm38

  41817 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27970  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: TGM_EBP42
Gene Tree: Tgm6

Human
homologs
Human Homolog TGM6, transglutaminase 6
NCBI Gene ID 343641
neXtProt AC  NX_O95932
Human Synonyms  dJ734P14.3, SCA35, TG6, TGM3L, TGY
Human Chr (Location)  20p13; chr20:2380908-2432753 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TGM6
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Tgm6 interacts with 148 markers (Mir18, Mir18b, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process biological_process
Component cytoplasm
Function metal ion binding, protein-glutamine gamma-glutamyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(5) cDNA(4) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000015503 (Evidence)
Ensembl Gene ModelENSMUSG00000027403 (Evidence)
Entrez Gene241636 (Evidence)
UniGene83437
DFCITC1588543
DoTSDT.102520171, DT.102550220, DT.111153845, DT.91419737, DT.94144034
NIA Mouse Gene IndexU002467
EC2.3.2.13
Consensus CDS ProjectCCDS16734.1
International Mouse Knockout Project StatusTgm6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015503 VEGA Gene Model | MGI Sequence Detail 41817 C57BL/6J ±  kb
transcript OTTMUST00000036815 VEGA | MGI Sequence Detail 3327 Not Applicable 
polypeptide OTTMUSP00000016517 VEGA | MGI Sequence Detail 706 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(10) UniProt(8)
Polymorphisms
SNPs within 2kb(499 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR023608 Protein-glutamine gamma-glutamyltransferase, eukaryota
InterPro IPR013808 Transglutaminase, conserved site
InterPro IPR008958 Transglutaminase, C-terminal
InterPro IPR002931 Transglutaminase-like
InterPro IPR001102 Transglutaminase, N-terminal
Protein Ontology PR:000016297 protein-glutamine gamma-glutamyltransferase 6
References
(Earliest) J:122989 Visel A, et al., GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
(Latest) J:193871 Guan WJ, et al., Spinocerebellar ataxia type 35 (SCA35)-associated transglutaminase 6 mutants sensitize cells to apoptosis. Biochem Biophys Res Commun. 2013 Jan 11;430(2):780-6
All references(27)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory