About   Help   FAQ
Tgm6 Gene Detail
Summary
  • Symbol
    Tgm6
  • Name
    transglutaminase 6
  • Synonyms
    TGM3L
  • Feature Type
    protein coding gene
  • IDs
    MGI:3044321
    NCBI Gene: 241636
  • Gene Overview
    MyGene.info: TGM6
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:130112416-130154232 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    499 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3044321
protein coding gene Chr2:130112416-130154232 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026494
protein coding gene Chr2:133536573-133593716 (+)
A/J MGP_AJ_G0026458
protein coding gene Chr2:128148756-128190499 (+)
AKR/J MGP_AKRJ_G0026433
protein coding gene Chr2:131813911-131857644 (+)
BALB/cJ MGP_BALBcJ_G0026470
protein coding gene Chr2:128500814-128543766 (+)
C3H/HeJ MGP_C3HHeJ_G0026213
protein coding gene Chr2:132271583-132313307 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026915
protein coding gene Chr2:137690642-137734947 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024292
protein coding gene Chr2:122895030-122935963 (+)
CAST/EiJ MGP_CASTEiJ_G0025674
protein coding gene Chr2:132514410-132564298 (+)
CBA/J MGP_CBAJ_G0026193
protein coding gene Chr2:142783079-142833703 (+)
DBA/2J MGP_DBA2J_G0026327
protein coding gene Chr2:127536827-127578673 (+)
FVB/NJ MGP_FVBNJ_G0026291
protein coding gene Chr2:126157478-126199096 (+)
LP/J MGP_LPJ_G0026432
protein coding gene Chr2:133793155-133836353 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026311
protein coding gene Chr2:146646136-146693895 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026970
protein coding gene Chr2:131790859-131836284 (+)
PWK/PhJ MGP_PWKPhJ_G0025410
protein coding gene Chr2:127087477-127131381 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025212
protein coding gene Chr2:130917601-130960070 (+)
WSB/EiJ MGP_WSBEiJ_G0025748
protein coding gene Chr2:132718102-132764800 (+)



Homology
more
  • Human Ortholog
    TGM6, transglutaminase 6
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TGM6, transglutaminase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ734P14.3, SCA35, TG6, TGM3L, TGY
  • Links
    NCBI Gene ID: 343641
    neXtProt AC: NX_O95932
    UniProt: O95932

  • Chr Location
    20p13; chr20:2380908-2432753 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TGM6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 241636 NCBI Gene Model | MGI Sequence Detail 41817 C57BL/6J ±  kb
    transcript NM_001289747 RefSeq | MGI Sequence Detail 3471 C57BL/6  
    polypeptide NP_808394 RefSeq | MGI Sequence Detail 706 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 27
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:213110 Fukui M, et al., Identification of a highly reactive substrate peptide for transglutaminase 6 and its use in detecting transglutaminase activity in the skin epidermis. FEBS J. 2013 Mar;280(6):1420-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory