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Neurl2 Gene Detail
Summary
  • Symbol
    Neurl2
  • Name
    neuralized E3 ubiquitin protein ligase 2
  • Synonyms
    Ozz, Ozz-E3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3043305
    NCBI Gene: 415115
  • Gene Overview
    MyGene.info: NEURL2
Location & Maps
more
  • Sequence Map
    Chr2:164830732-164833456 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2725 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 85.27 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NEURL2, neuralized E3 ubiquitin protein ligase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NEURL2, neuralized E3 ubiquitin protein ligase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C20orf163, OZZ, OZZ-E3
  • Links
    NCBI Gene ID: 140825
    neXtProt AC: NX_Q9BR09

  • Chr Location
    20q13.12; chr20:45888472-45891287 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Gene trapped
    17
  • Targeted
    6
Homozygous null mice display myofiber abnormalities in skeletal muscle and decreased body weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001109 VEGA Gene Model | MGI Sequence Detail 2725 C57BL/6J ±  kb
transcript OTTMUST00000002175 VEGA | MGI Sequence Detail 1014 Not Applicable  
polypeptide OTTMUSP00000001062 VEGA | MGI Sequence Detail 285 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    37 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011150 neuralized-like protein 2
  • InterPro Domains
    IPR006573 Neuralized homology repeat (NHR) domain
    IPR001496 SOCS box domain
Molecular
Reagents
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  • All nucleic 4
    cDNA 2
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 30
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:40589 Rottier RJ, et al., Identification of the promoters for the human and murine protective protein/cathepsin A genes. DNA Cell Biol. 1997 May;16(5):599-610
  • Latest
    J:158726 Campos Y, et al., Ozz-E3 ubiquitin ligase targets sarcomeric embryonic myosin heavy chain during muscle development. PLoS One. 2010;5(3):e9866

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory