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Prmt8 Gene Detail
Summary
  • Symbol
    Prmt8
  • Name
    protein arginine N-methyltransferase 8
  • Synonyms
    Hrmt1l3, Hrmt1l4
  • Feature Type
    protein coding gene
  • IDs
    MGI:3043083
    NCBI Gene: 381813
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:127689011-127769472 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 62.49 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    675 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3043083
protein coding gene Chr6:127689009-127769487 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031316
protein coding gene Chr6:131223913-131305991 (-)
A/J MGP_AJ_G0031287
protein coding gene Chr6:126211975-126293340 (-)
AKR/J MGP_AKRJ_G0031215
protein coding gene Chr6:129616004-129698176 (-)
BALB/cJ MGP_BALBcJ_G0031294
protein coding gene Chr6:125774624-125856342 (-)
C3H/HeJ MGP_C3HHeJ_G0031018
protein coding gene Chr6:129760280-129844417 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031751
protein coding gene Chr6:134650797-134735350 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028899
protein coding gene Chr6:123384847-123466550 (-)
CAST/EiJ MGP_CASTEiJ_G0030399
protein coding gene Chr6:129984608-130071927 (-)
CBA/J MGP_CBAJ_G0030979
protein coding gene Chr6:139817705-139907401 (-)
DBA/2J MGP_DBA2J_G0031135
protein coding gene Chr6:125102335-125183268 (-)
FVB/NJ MGP_FVBNJ_G0031084
protein coding gene Chr6:124025328-124108579 (-)
LP/J MGP_LPJ_G0031215
protein coding gene Chr6:131319426-131400652 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031123
protein coding gene Chr6:143731382-143816056 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031786
protein coding gene Chr6:129596634-129681426 (-)
PWK/PhJ MGP_PWKPhJ_G0030114
protein coding gene Chr6:123363457-123464969 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029943
protein coding gene Chr6:127696263-127781824 (-)
WSB/EiJ MGP_WSBEiJ_G0030484
protein coding gene Chr6:129966291-130050098 (-)



Homology
more
  • Human Ortholog
    PRMT8, protein arginine methyltransferase 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRMT8, protein arginine methyltransferase 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HRMT1L3, HRMT1L4
  • Links
    NCBI Gene ID: 56341
    neXtProt AC: NX_Q9NR22
    UniProt: Q9NR22

  • Chr Location
    12p13.32; chr12:3381349-3593973 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit abnormal Purkinje cell dendrite morphology, hyperactivity, limb grasping and gait abnormalities, and show reduced levels of acetylcholine and choline along with increased phosphatidylcholine levels in the cerebellum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030350 Ensembl Gene Model | MGI Sequence Detail 80462 C57BL/6J ±  kb
    transcript ENSMUST00000032500 Ensembl | MGI Sequence Detail 2724 Not Applicable  
    polypeptide ENSMUSP00000032500 Ensembl | MGI Sequence Detail 394 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 2
      cDNA 14
      Primer pair 2

      Microarray probesets 1
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:85485 Alappat SR, et al., Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis. Dev Dyn. 2003 Sep;228(1):59-71
    • Latest
      J:264455 Simandi Z, et al., Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons. J Neurosci. 2018 Aug 29;38(35):7683-7700

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/14/2019
    MGI 6.14
    The Jackson Laboratory