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Prmt8 Gene Detail
Summary
  • Symbol
    Prmt8
  • Name
    protein arginine N-methyltransferase 8
  • Synonyms
    Hrmt1l3, Hrmt1l4
  • Feature Type
    protein coding gene
  • IDs
    MGI:3043083
    NCBI Gene: 381813
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:127689011-127769472 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      80462 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 62.49 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PRMT8, protein arginine methyltransferase 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRMT8, protein arginine methyltransferase 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HRMT1L3, HRMT1L4
  • Links
    NCBI Gene ID: 56341
    neXtProt AC: NX_Q9NR22
    UniProt: Q9NR22

  • Chr Location
    12p13.32; chr12:3381349-3593973 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit abnormal Purkinje cell dendrite morphology, hyperactivity, limb grasping and gait abnormalities, and show reduced levels of acetylcholine and choline along with increased phosphatidylcholine levels in the cerebellum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020414 VEGA Gene Model | MGI Sequence Detail 80462 C57BL/6J ±  kb
    transcript OTTMUST00000048474 VEGA | MGI Sequence Detail 2724 Not Applicable  
    polypeptide OTTMUSP00000022227 VEGA | MGI Sequence Detail 394 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      675 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 2
      cDNA 13
      Primer pair 1

      Microarray probesets 1
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:85485 Alappat SR, et al., Mouse pigpen encodes a nuclear protein whose expression is developmentally regulated during craniofacial morphogenesis. Dev Dyn. 2003 Sep;228(1):59-71
    • Latest
      J:264455 Simandi Z, et al., Arginine Methyltransferase PRMT8 Provides Cellular Stress Tolerance in Aging Motoneurons. J Neurosci. 2018 Aug 29;38(35):7683-7700

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory