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Itprip
Gene Detail
Symbol

Name
ID
Itprip
inositol 1,4,5-triphosphate receptor interacting protein
MGI:3042776
Synonyms
DANGER
Feature Type
protein coding gene
Genetic Map
Chromosome 19
40.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:47894593-47919519 bp, - strand
From NCBI annotation of GRCm38

  24927 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:62157  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ITPRIP

Human
homologs
ITPRIP, inositol 1,4,5-trisphosphate receptor interacting protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 85450
neXtProt AC: NX_Q8IWB1

Human Synonyms: bA127L20, bA127L20.2, DANGER, KIAA1754

Human Chr (Location): 10q25.1; chr10:104309696-104338493 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a null mutation are grossly normal, but MEF and neuronal cells show increased susceptibility to induced cell death due to increase in death-associated protein kinase (DAPK) activity.
 
Interactions
Itprip interacts with 235 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
cDNA source data(11)
Other mouse links: Allen Institute   GEO  
Other vertebrate links: Xenbase itprip ; ZFIN itprip    NEW 
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(3)
Other database
links
Entrez Gene 414801 (Evidence)
DFCI TC1576303, TC1630904, TC1644910
DoTS DT.101341754, DT.102556689, DT.55231454, DT.99851521
Consensus CDS Project CCDS29895.1
International Mouse Phenotyping Consortium Status Itprip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 414801 NCBI Gene Model | MGI Sequence Detail 24927 C57BL/6J ±  kb
transcript NM_001001738 RefSeq | MGI Sequence Detail 3781 C57BL/6 
polypeptide Q3TNL8 UniProt | EBI | MGI Sequence Detail 555 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(256 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024797 Inositol 1,4,5-trisphosphate receptor-interacting protein
InterPro IPR026250 Inositol 1,4,5-trisphosphate receptor-interacting protein family
InterPro IPR024810 Mab-21 domain
Protein Ontology PR:000009161 inositol 1,4,5-trisphosphate receptor-interacting protein
Graphical View of Protein Domain Structure
References
(Earliest) J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(21)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory