Serpinb13 MGI Mouse Gene Detail - MGI:3042250 - serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13

Symbol

Serpinb13
Name

serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 13
Synonyms

headpin, HUR7, HURPIN, PI13

Feature Type

protein coding gene
IDs

MGI:3042250
NCBI Gene: 241196
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr1:106908714-106928925 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 50.34 cM
Mapping Data

2 experiments

SNPs within 2kb

683 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3042250	protein coding gene	Chr1:106908714-106928925 (+)
129S1/SvImJ	ENSMUSG00200000321	protein coding gene	Chr1:104213652-104233857 (+)
A/J	ENSMUSG00195007788	protein coding gene	Chr1:103692828-103713023 (+)
AKR/J	ENSMUSG00220000193	protein coding gene	Chr1:103784772-103804967 (+)
BALB/cJ	ENSMUSG00180000324	protein coding gene	Chr1:103978651-103998843 (+)
C3H/HeJ	ENSMUSG00175000539	protein coding gene	Chr1:103907893-103928082 (+)
C57BL/6NJ	ENSMUSG00215006560	protein coding gene	Chr1:103903740-103923961 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014493	protein coding gene	Chr1:99641826-99663927 (+)
CAST/EiJ	ENSTCUG00005002764	protein coding gene	Chr1:103233602-103253747 (+)
CBA/J	ENSMUSG00210000089	protein coding gene	Chr1:103788010-103808200 (+)
DBA/2J	ENSMUSG00185008123	protein coding gene	Chr1:108236910-108257112 (+)
FVB/NJ	ENSMUSG00205007791	protein coding gene	Chr1:103092239-103112432 (+)
JF1/MsJ	ENSUMUG00000000110	protein coding gene	Chr1:106815028-106835291 (+)
LP/J	ENSMUSG00230000068	protein coding gene	Chr1:107499632-107519837 (+)
NOD/ShiLtJ	ENSMUSG00190000388	protein coding gene	Chr1:103847348-103867553 (+)
NZO/HlLtJ	ENSMUSG00225000255	protein coding gene	Chr1:111383135-111403291 (+)
PWK/PhJ	ENSLUMG00010000128	protein coding gene	Chr1:103222260-103242519 (+)
SPRET/EiJ	ENSMSPG00010000500	protein coding gene	Chr1:105504352-105525379 (+)
WSB/EiJ	ENSIUOG00005000946	protein coding gene	Chr1:103593663-103613881 (+)

Human Ortholog

SERPINB13, serpin family B member 13

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPINB13, serpin family B member 13
Synonyms

headpin, HSHUR7SEQ, HUR7, PI13
Links

HGNC:8944

NCBI Gene ID: 5275

UniProt: Q9UIV8
Chr Location

18q21.33; chr18:63586989-63604639 (+) GRCh38

MGI Vertebrate Homology

Serpinb13 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SERPINB13
Gene Tree

Serpinb13

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Targeted

2
Genomic Mutations

3 involving Serpinb13
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available

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All GO Annotations

18
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

599
Tissues

2
cDNA Data

3
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

32
RefSeq

2
UniProt

2
CCDS

CCDS15213.1

Ensembl

ENSMUSG00000048775 (Evidence)
NCBI Gene

241196

			Length	Strain/Species	Flank
genomic	241196	NCBI Gene Model \| MGI Sequence Detail	20212	C57BL/6J	± kb
transcript	NM_172852	RefSeq \| MGI Sequence Detail	1607	C57BL/6
polypeptide	Q8CDC0	UniProt \| EBI \| MGI Sequence Detail	389	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014693 serpin B13

(term hierarchy)
InterPro Domains

IPR023795 Serpin, conserved site

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2

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All nucleic 8

Genomic 5

cDNA 3

Antibodies 1

Microarray probesets 1

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 9
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:376166 Kryvalap Y, et al., SerpinB13 antibodies promote beta cell development and resistance to type 1 diabetes. Sci Transl Med. 2021 Apr 7;13(588):eabf1587

TSS for Serpinb13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8327	Chr1:106908709-106908715 (+)	-2 bp
Tssr8328	Chr1:106926318-106926331 (+)	17,611 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24