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Nfkbid Gene Detail
Summary
  • Symbol
    Nfkbid
  • Name
    nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
  • Synonyms
    IkappaBNS
  • Feature Type
    protein coding gene
  • IDs
    MGI:3041243
    NCBI Gene: 243910
  • Gene Overview
    MyGene.info: NFKBID
Location & Maps
more
  • Sequence Map
    Chr7:30421732-30428746 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7015 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 17.52 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NFKBID, NFKB inhibitor delta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NFKBID, NFKB inhibitor delta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IkappaBNS, TA-NFKBH
  • Links
    NCBI Gene ID: 84807
    neXtProt AC: NX_Q8NI38

  • Chr Location
    19q13.12; chr19:35887129-35902334 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    1
  • Gene trapped
    4
  • Targeted
    5
  • Incidental Mutations
Mice homozygous for a null allele produce higher levels of IL-6 following stimulation and are more susceptible to chemically induced endotoxin shock and colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026225 VEGA Gene Model | MGI Sequence Detail 7015 C57BL/6J ±  kb
transcript OTTMUST00000064861 VEGA | MGI Sequence Detail 2014 Not Applicable  
polypeptide OTTMUSP00000032249 VEGA | MGI Sequence Detail 327 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    218 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011179 NF-kappa-B inhibitor delta
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR020683 Ankyrin repeat-containing domain
Molecular
Reagents
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  • All nucleic 12
    cDNA 12

    Microarray probesets 2
References
more
  • Summaries
    All 36
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:75807 Fiorini E, et al., Peptide-induced negative selection of thymocytes activates transcription of an NF-kappaB inhibitor. Mol Cell. 2002 Mar;9(3):637-48
  • Latest
    J:223097 Kobayashi S, et al., The nuclear IkappaB family protein IkappaBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model. PLoS One. 2014;9(10):e110838

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory