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Nfkbid
Gene Detail
Symbol

Name
ID
Nfkbid
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta
MGI:3041243
Synonyms
IkappaBNS
Feature Type
protein coding gene
Genetic Map
Chromosome 7
17.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:30421732-30428746 bp, + strand
From VEGA annotation of GRCm38

  7015 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:13101  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NFKBID
Gene Tree: Nfkbid

Human
homologs
NFKBID, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 84807
neXtProt AC: NX_Q8NI38

Human Synonyms: IkappaBNS, TA-NFKBH

Human Chr (Location): 19q13.12; chr19:35887129-35902334 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(4) Targeted(5)
Incidental mutations (data from CvDC )
 
Mice homozygous for a null allele produce higher levels of IL-6 following stimulation and are more susceptible to chemically induced endotoxin shock and colitis.
 
Interactions
Nfkbid interacts with 75 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process inflammatory response, negative regulation of I-kappaB kinase/NF-kappaB signaling, ...
Component nucleus
Function NF-kappaB binding, protein binding
External Resources: FuncBase
Expression
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(12)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000026225 (Evidence)
Ensembl Gene Model ENSMUSG00000036931 (Evidence)
Entrez Gene 243910 (Evidence)
UniGene 386878
DFCI TC1583595
DoTS DT.526455, DT.91335287, DT.99853584
NIA Mouse Gene Index U007929
Consensus CDS Project CCDS21091.1
International Mouse Phenotyping Consortium Status Nfkbid
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026225 VEGA Gene Model | MGI Sequence Detail 7015 C57BL/6J ±  kb
transcript OTTMUST00000064861 VEGA | MGI Sequence Detail 2014 Not Applicable 
polypeptide OTTMUSP00000032249 VEGA | MGI Sequence Detail 327 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(235 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000011179 NF-kappa-B inhibitor delta
References
(Earliest) J:75807 Fiorini E, et al., Peptide-induced negative selection of thymocytes activates transcription of an NF-kappaB inhibitor. Mol Cell. 2002 Mar;9(3):637-48
(Latest) J:216474 Pedersen GK, et al., B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IkappaBNS. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4119-26
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory