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Akip1 Gene Detail
Summary
  • Symbol
    Akip1
  • Name
    A kinase interacting protein 1
  • Synonyms
    BCA3, D7H11orf17, D930014E17Rik, ICRFP703B1614Q5.6, ICRFP703N2430Q5.6, ORF27
  • Feature Type
    protein coding gene
  • IDs
    MGI:3041226
    NCBI Gene: 57373
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:109302897-109311396 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 57.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3041226
 protein coding gene Chr7:109302885-109311396 (+)
129S1/SvImJ ENSMUSG00200031929
 protein coding gene Chr7:95844906-95853405 (+)
A/J ENSMUSG00195054197
 protein coding gene Chr7:100340951-100349461 (+)
AKR/J ENSMUSG00220037755
 protein coding gene Chr7:93744417-93752928 (+)
BALB/cJ ENSMUSG00180039883
 protein coding gene Chr7:97016313-97024812 (+)
C3H/HeJ ENSMUSG00175047683
 protein coding gene Chr7:97652281-97660780 (+)
C57BL/6NJ ENSMUSG00215047879
 protein coding gene Chr7:96957123-96965622 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030311
 protein coding gene Chr7:111917547-111925920 (+)
CAST/EiJ ENSTCUG00005052351
 protein coding gene Chr7:100327536-100336057 (+)
CBA/J ENSMUSG00210035473
 protein coding gene Chr7:97479437-97487936 (+)
DBA/2J ENSMUSG00185020366
 protein coding gene Chr7:101829702-101838201 (+)
FVB/NJ ENSMUSG00205045356
 protein coding gene Chr7:97441672-97450171 (+)
JF1/MsJ ENSUMUG00000039309
 protein coding gene Chr7:106843749-106852262 (+)
LP/J ENSMUSG00230043828
 protein coding gene Chr7:107930722-107939221 (+)
NOD/ShiLtJ ENSMUSG00190041030
 protein coding gene Chr7:97639080-97647583 (+)
NZO/HlLtJ ENSMUSG00225015670
 protein coding gene Chr7:106148960-106157469 (+)
PWK/PhJ ENSLUMG00010036456
 protein coding gene Chr7:95961089-95969580 (+)
SPRET/EiJ ENSMSPG00010040936
 protein coding gene Chr7:97122225-97131874 (+)
WSB/EiJ ENSIUOG00005046648
 protein coding gene Chr7:98274844-98283342 (+)



Homology
more
  • Human Ortholog
    AKIP1, A-kinase interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKIP1, A-kinase interacting protein 1
  • Synonyms
    BCA3, C11orf17
  • Links
    NCBI Gene ID: 56672
    UniProt: Q9NQ31

  • Chr Location
    11p15.4; chr11:8911113-8922406 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    17
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Akip1
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    22 strains or lines available
Mice homozygous for a null allele show lower thrombomodulin and fibrinogen levels, shorter prothrombin time and tail bleeding time, and lower mortality due to LPS challenge, when infected with the VP35 of Ebola virus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    604
  • Tissues
    7
  • cDNA Data
    35
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031023 Ensembl Gene Model | MGI Sequence Detail 8500 C57BL/6J ±  kb
transcript ENSMUST00000033335 Ensembl | MGI Sequence Detail 1028 Not Applicable  
polypeptide ENSMUSP00000033335 Ensembl | MGI Sequence Detail 212 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 3
    cDNA 35

    Microarray probesets 3
Other
Accession IDs
less
MGI:1928826, MGI:2152418
References
more
  • Summaries
    All 57
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 21
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory