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Adgrd1 Gene Detail
Summary
  • Symbol
    Adgrd1
  • Name
    adhesion G protein-coupled receptor D1
  • Synonyms
    E230012M21Rik, Gpr133
  • Feature Type
    protein coding gene
  • IDs
    MGI:3041203
    NCBI Gene: 243277
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:129173814-129281663 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 67.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3515 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3041203
 protein coding gene Chr5:129173741-129281663 (+)
129S1/SvImJ ENSMUSG00200045988
 protein coding gene Chr5:122909008-123027652 (+)
A/J ENSMUSG00195043472
 protein coding gene Chr5:122443231-122561714 (+)
AKR/J ENSMUSG00220049276
 protein coding gene Chr5:121928322-122036200 (+)
BALB/cJ ENSMUSG00180034697
 protein coding gene Chr5:122550644-122669123 (+)
C3H/HeJ ENSMUSG00175039015
 protein coding gene Chr5:124528058-124635939 (+)
C57BL/6NJ ENSMUSG00215048769
 protein coding gene Chr5:122590105-122697970 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027779
 protein coding gene Chr5:121964455-122083044 (+)
CAST/EiJ ENSTCUG00005008856
 protein coding gene Chr5:121791770-121910104 (+)
CBA/J ENSMUSG00210006031
 protein coding gene Chr5:123278742-123386633 (+)
DBA/2J ENSMUSG00185007355
 protein coding gene Chr5:126330666-126438531 (+)
FVB/NJ ENSMUSG00205025838
 protein coding gene Chr5:122200076-122318800 (+)
JF1/MsJ ENSUMUG00000033891
 protein coding gene Chr5:129205590-129323710 (+)
LP/J ENSMUSG00230042289
 protein coding gene Chr5:130424929-130543567 (+)
NOD/ShiLtJ ENSMUSG00190026892
 protein coding gene Chr5:122229051-122347863 (+)
NZO/HlLtJ ENSMUSG00225013445
 protein coding gene Chr5:138123683-138241778 (+)
PWK/PhJ ENSLUMG00010016201
 protein coding gene Chr5:121091706-121209870 (+)
SPRET/EiJ ENSMSPG00010026479
 protein coding gene Chr5:124426504-124542782 (+)
WSB/EiJ ENSIUOG00005029238
 protein coding gene Chr5:124901269-125019794 (+)



Homology
more
  • Human Ortholog
    ADGRD1, adhesion G protein-coupled receptor D1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRD1, adhesion G protein-coupled receptor D1
  • Synonyms
    GPR133, PGR25
  • Links
    NCBI Gene ID: 283383
    UniProt: Q6QNK2

  • Chr Location
    12q24.33; chr12:130953055-131142466 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit female infertility associated with failure to overcome the tubal-locking following fertilization and reduced oviductal luminal fluid production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    633
  • Tissues
    20
  • cDNA Data
    16
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044017 Ensembl Gene Model | MGI Sequence Detail 107850 C57BL/6J ±  kb
    transcript ENSMUST00000056617 Ensembl | MGI Sequence Detail 5163 Not Applicable  
    polypeptide ENSMUSP00000060307 Ensembl | MGI Sequence Detail 903 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR046338 GAIN domain superfamily
      IPR057244 GAIN, subdomain B
      IPR017981 GPCR, family 2-like, 7TM
      IPR000832 GPCR, family 2, secretin-like
      IPR017983 GPCR, family 2, secretin-like, conserved site
      IPR000203 GPS motif
      IPR001759 Pentraxin domain
    • GlyGen
      Q80T32 14 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 24
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:375698 Yang Z, et al., A force-sensitive adhesion GPCR is required for equilibrioception. Cell Res. 2025 Apr;35(4):243-264
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory