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Piwil4 Gene Detail
Summary
  • Symbol
    Piwil4
  • Name
    piwi-like RNA-mediated gene silencing 4
  • Synonyms
    9230101H05Rik, Miwi2, MIWI2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3041167
    NCBI Gene: 330890
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:14696230-14740721 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      44492 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 4.25 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PIWIL4, piwi like RNA-mediated gene silencing 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PIWIL4, piwi like RNA-mediated gene silencing 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HIWI2, MIWI2
  • Links
    NCBI Gene ID: 143689
    neXtProt AC: NX_Q7Z3Z4
    UniProt: Q7Z3Z4

  • Chr Location
    11q21; chr11:94567308-94621421 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit male specific-infertility with a progressive loss of male germ cells, reduced testis size, abnormal male meiosis and increased apoptosis of spermatocytes in seminiferous tubules.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024005 VEGA Gene Model | MGI Sequence Detail 44492 C57BL/6J ±  kb
    transcript OTTMUST00000058678 VEGA | MGI Sequence Detail 3304 Not Applicable  
    polypeptide OTTMUSP00000028473 VEGA | MGI Sequence Detail 848 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      406 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 22
      Gene Ontology 14
      Phenotypes 19
    • Earliest
      J:79881 Carmell MA, et al., The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev. 2002 Nov 1;16(21):2733-42
    • Latest
      J:247854 Wasserman GA, et al., Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells. J Clin Invest. 2017 Oct 02;127(10):3866-3876

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory