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Tnip3 Gene Detail
Summary
  • Symbol
    Tnip3
  • Name
    TNFAIP3 interacting protein 3
  • Synonyms
    9030611K07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:3041165
    NCBI Gene: 414084
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:65590398-65634040 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 30.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    517 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3041165
protein coding gene Chr6:65525313-65634040 (.)
129S1/SvImJ MGP_129S1SvImJ_G0030832
protein coding gene Chr6:65443634-65554020 (+)
A/J MGP_AJ_G0030799
protein coding gene Chr6:62592292-62702575 (+)
AKR/J MGP_AKRJ_G0030727
protein coding gene Chr6:64559233-64669553 (+)
BALB/cJ MGP_BALBcJ_G0030810
protein coding gene Chr6:62991499-63099286 (+)
C3H/HeJ MGP_C3HHeJ_G0030902
protein coding gene Chr6:119537063-119642609 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031268
protein coding gene Chr6:66970280-67083835 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028461
protein coding gene Chr6:59888240-59989101 (+)
CAST/EiJ MGP_CASTEiJ_G0029922
protein coding gene Chr6:64823815-64932585 (+)
CBA/J MGP_CBAJ_G0030497
protein coding gene Chr6:69744211-69858961 (+)
DBA/2J MGP_DBA2J_G0030649
protein coding gene Chr6:62284961-62398386 (+)
FVB/NJ MGP_FVBNJ_G0030602
protein coding gene Chr6:61816544-61920638 (+)
LP/J MGP_LPJ_G0030733
protein coding gene Chr6:65372518-65482862 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030637
protein coding gene Chr6:73518670-73565886 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031294
protein coding gene Chr6:64512342-64623338 (+)
PWK/PhJ MGP_PWKPhJ_G0029637
protein coding gene Chr6:61420851-61527979 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029465
protein coding gene Chr6:64103631-64157388 (+)
WSB/EiJ MGP_WSBEiJ_G0030004
protein coding gene Chr6:64801300-64907517 (+)



Homology
more
  • Human Ortholog
    TNIP3, TNFAIP3 interacting protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNIP3, TNFAIP3 interacting protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ABIN-3, LIND
  • Links
    NCBI Gene ID: 79931
    neXtProt AC: NX_Q96KP6
    UniProt: Q96KP6

  • Chr Location
    4q27; chr4:121127161-121227609 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotype references
Mice homozygous for a knock-out allele are viable and fertile and do not develop spontaneous inflammatory or autoimmune disease; mutant macrophages exhibit normal responses to IL-10 and LPS.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 414084 NCBI Gene Model | MGI Sequence Detail 43643 C57BL/6J ±  kb
transcript NM_001001495 RefSeq | MGI Sequence Detail 3769 Not Specified  
polypeptide NP_001001495 RefSeq | MGI Sequence Detail 208 Not Specified  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR033574 TNFAIP3-interacting protein 3
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 1
References
more
  • Summaries
    All 17
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 2
  • Earliest
    J:122758 Weaver BK, et al., ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions. Mol Cell Biol. 2007 Jul;27(13):4603-16
  • Latest
    J:262823 Kasowitz SD, et al., Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory