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Tnip3 Gene Detail
Summary
  • Symbol
    Tnip3
  • Name
    TNFAIP3 interacting protein 3
  • Synonyms
    9030611K07Rik
Location &
Maps
more
  • Sequence Map
    Chr6:65502297-65611024 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, Syntenic
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3005 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3041165
 protein coding gene Chr6:65502297-65611024 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030832
 protein coding gene Chr6:65443634-65554020 (+)
A/J MGP_AJ_G0030799
 protein coding gene Chr6:62592292-62702575 (+)
AKR/J MGP_AKRJ_G0030727
 protein coding gene Chr6:64559233-64669553 (+)
BALB/cJ MGP_BALBcJ_G0030810
 protein coding gene Chr6:62991499-63099286 (+)
C3H/HeJ MGP_C3HHeJ_G0030902
 protein coding gene Chr6:119537063-119642609 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031268
 protein coding gene Chr6:66970280-67083835 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028461
 protein coding gene Chr6:59888240-59989101 (+)
CAST/EiJ MGP_CASTEiJ_G0029922
 protein coding gene Chr6:64823815-64932585 (+)
CBA/J MGP_CBAJ_G0030497
 protein coding gene Chr6:69744211-69858961 (+)
DBA/2J MGP_DBA2J_G0030649
 protein coding gene Chr6:62284961-62398386 (+)
FVB/NJ MGP_FVBNJ_G0030602
 protein coding gene Chr6:61816544-61920638 (+)
LP/J MGP_LPJ_G0030733
 protein coding gene Chr6:65372518-65482862 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030637
 protein coding gene Chr6:73518670-73565886 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031294
 protein coding gene Chr6:64512342-64623338 (+)
PWK/PhJ MGP_PWKPhJ_G0029637
 protein coding gene Chr6:61420851-61527979 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029465
 protein coding gene Chr6:64103631-64157388 (+)
WSB/EiJ MGP_WSBEiJ_G0030004
 protein coding gene Chr6:64801300-64907517 (+)



Homology
more
  • Human Ortholog
    TNIP3, TNFAIP3 interacting protein 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNIP3, TNFAIP3 interacting protein 3
  • Synonyms
    ABIN-3, LIND
  • Links
    NCBI Gene ID: 79931
    UniProt: Q96KP6

  • Chr Location
    4q27; chr4:121131408-121227483 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    3 phenotype references
Mice homozygous for a knock-out allele are viable and fertile and do not develop spontaneous inflammatory or autoimmune disease; mutant macrophages exhibit normal responses to IL-10 and LPS.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044162 Ensembl Gene Model | MGI Sequence Detail 108728 C57BL/6J ±  kb
transcript ENSMUST00000212375 Ensembl | MGI Sequence Detail 1543 Not Applicable  
polypeptide ENSMUSP00000148845 Ensembl | MGI Sequence Detail 279 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
Molecular
Reagents
less
  • All nucleic 6
    cDNA 6

    Microarray probesets 1
Other
Accession IDs
less
MGI:6468421
References
more
  • Summaries
    All 20
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 3
  • Earliest
    J:122758 Weaver BK, et al., ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions. Mol Cell Biol. 2007 Jul;27(13):4603-16
  • Latest
    J:287731 Liu D, et al., TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation. Cell Metab. 2020 Apr 7;31(4):726-740.e8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory