Clec12a MGI Mouse Gene Detail - MGI:3040968 - C-type lectin domain family 12, member a

Symbol

Clec12a
Name

C-type lectin domain family 12, member a
Synonyms

Micl

Feature Type

protein coding gene
IDs

MGI:3040968
NCBI Gene: 232413
Alliance

genome feature page
Transcription Start Sites

18 TSS

Sequence Map

Chr6:129327207-129342266 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 63.26 cM
Mapping Data

1 experiment

SNPs within 2kb

567 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3040968	protein coding gene	Chr6:129319654-129342266 (+)
129S1/SvImJ	ENSMUSG00200043102	protein coding gene	Chr6:126423358-126445967 (+)
A/J	ENSMUSG00195028121	protein coding gene	Chr6:125844238-125866883 (+)
AKR/J	ENSMUSG00220036707	protein coding gene	Chr6:124705853-124728486 (+)
BALB/cJ	ENSMUSG00180031899	protein coding gene	Chr6:126181222-126203836 (+)
C3H/HeJ	ENSMUSG00175035942	protein coding gene	Chr6:125861413-125884042 (+)
C57BL/6NJ	ENSMUSG00215015378	protein coding gene	Chr6:126149906-126172521 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028927	protein coding gene	Chr6:126247457-126262905 (+)
CAST/EiJ	ENSTCUG00005039561	protein coding gene	Chr6:126179893-126202674 (+)
CBA/J	ENSMUSG00210016495	protein coding gene	Chr6:125881252-125903873 (+)
DBA/2J	ENSMUSG00185037000	protein coding gene	Chr6:126582009-126604628 (+)
FVB/NJ	ENSMUSG00205026587	protein coding gene	Chr6:125433476-125456116 (+)
JF1/MsJ	ENSUMUG00000036576	protein coding gene	Chr6:125196895-125219658 (+)
LP/J	ENSMUSG00230038609	protein coding gene	Chr6:127778643-127801260 (+)
NOD/ShiLtJ	ENSMUSG00190025533	protein coding gene	Chr6:125584654-125607327 (+)
NZO/HlLtJ	ENSMUSG00225015365	protein coding gene	Chr6:130056813-130078926 (+)
PWK/PhJ	ENSLUMG00010039025	protein coding gene	Chr6:124380983-124403797 (+)
SPRET/EiJ	ENSMSPG00010030537	protein coding gene	Chr6:127117948-127140723 (+)
WSB/EiJ	ENSIUOG00005043680	protein coding gene	Chr6:126304727-126327364 (+)

Human Ortholog

CLEC12A, C-type lectin domain family 12 member A

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLEC12A, C-type lectin domain family 12 member A
Synonyms

CD371, CLL-1, CLL1, DCAL-2, hKLRL1, MICL
Links

HGNC:31713

NCBI Gene ID: 160364

UniProt: Q5QGZ9
Chr Location

12p13.31-p13.2; chr12:9951268-10006150 (+) GRCh38

MGI Vertebrate Homology

Clec12a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CLEC12A
Gene Tree

Clec12a

less

Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

7
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Mice homozygous for a null allele exhibit hyperinflammatory responses following challenge with uric acid crystals (monosodium urate) or necrotic cells and after radiation-induced thymocyte killing. Homozygotes for a different null allele show increased susceptibility to bacterial infection.

less

All GO Annotations

37
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

659
Tissues

5
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS20584.1

Ensembl

ENSMUSG00000053063 (Evidence)
NCBI Gene

232413

			Length	Strain/Species	Flank
genomic	232413	NCBI Gene Model \| MGI Sequence Detail	15060	C57BL/6J	± kb
transcript	NM_177686	RefSeq \| MGI Sequence Detail	2222	C57BL/6
polypeptide	Q504P2	UniProt \| EBI \| MGI Sequence Detail	267	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000005559 C-type lectin domain family 12 member A

(term hierarchy)
InterPro Domains

IPR042916 C-type lectin domain family 12 member A/B

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
GlyGen

Q504P2 4 sites, 1 N-linked glycan (1 site)

less

All nucleic 8

cDNA 8

Microarray probesets 2

Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 15

Phenotypes 13
Earliest

J:89520 Marshall AS, et al., Identification and characterization of a novel human myeloid inhibitory C-type lectin-like receptor (MICL) that is predominantly expressed on granulocytes and monocytes. J Biol Chem. 2004 Apr 9;279(15):14792-802
Latest

J:387084 Yang Z, et al., CARD9 orchestrates tissue damage in APAP-induced hepatitis via TREM2-mediated sensing cell death. J Immunol. 2026 Jan 21;215(1)

TSS for Clec12a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59139	Chr6:129326701-129326713 (+)	-500 bp
Tssr59140	Chr6:129327166-129327173 (+)	-37 bp
Tssr59141	Chr6:129327185-129327194 (+)	-17 bp
Tssr59142	Chr6:129327200-129327212 (+)	-1 bp
Tssr59143	Chr6:129327222-129327233 (+)	21 bp
Tssr59144	Chr6:129327245-129327260 (+)	46 bp
Tssr59145	Chr6:129327272-129327294 (+)	76 bp
Tssr59146	Chr6:129327296-129327301 (+)	92 bp
Tssr59147	Chr6:129327311-129327337 (+)	117 bp
Tssr59148	Chr6:129327340-129327354 (+)	140 bp
Tssr59149	Chr6:129327417-129327426 (+)	215 bp
Tssr2029	Chr6:129327442-129327454 (+)	241 bp
Tssr59150	Chr6:129328386-129328400 (+)	1,186 bp
Tssr59151	Chr6:129328415-129328444 (+)	1,223 bp
Tssr59152	Chr6:129329674-129329691 (+)	2,476 bp
Tssr59153	Chr6:129330394-129330417 (+)	3,199 bp
Tssr59154	Chr6:129336722-129336729 (+)	9,519 bp
Tssr59155	Chr6:129338846-129338853 (+)	11,643 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24