About   Help   FAQ
Palb2
Gene Detail
 Symbol
Name
ID
Palb2
partner and localizer of BRCA2
MGI:3040695
Feature Type protein coding gene
Genetic Map
Chromosome 7
65.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:122107262-122132946 bp, - strand
From VEGA annotation of GRCm38

  25685 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11652  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: Partner and localizer of BRCA2
Gene Tree: Palb2

Human
homologs
Human Homolog PALB2, partner and localizer of BRCA2
NCBI Gene ID 79728
neXtProt AC  NX_Q86YC2
Human Synonyms  FANCN, PNCA3
Human Chr (Location)  16p12.2; chr16:23603162-23641357 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human PALB2
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(11) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display embryonic lethality with impaired inner cell mass proliferation, impaired gastrulation, absence of the amnion, somites and tail bud, and general improper organogenesis.
 
Interactions
Palb2 interacts with 372 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cellular response to DNA damage stimulus, DNA recombination, ...
Component nucleus
Function DNA binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (6)    Tissues (4)   
Theiler Stages: 11, 13
Assay TypeResults
In situ reporter (knock in) 4
RT-PCR 2
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(11) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022651 (Evidence)
Ensembl Gene ModelENSMUSG00000044702 (Evidence)
Entrez Gene233826 (Evidence)
DFCITC1582034, TC1586863, TC1596811, TC1613592
DoTSDT.101382008, DT.102556174, DT.110997826, DT.110997828, DT.482675, DT.94296241, DT.99846769, DT.99854689
NIA Mouse Gene IndexU029212
Consensus CDS ProjectCCDS40117.1, CCDS72035.1
International Mouse Knockout Project StatusPalb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022651 VEGA Gene Model | MGI Sequence Detail 25685 C57BL/6J ±  kb
transcript OTTMUST00000054269 VEGA | MGI Sequence Detail 3750 Not Applicable 
polypeptide OTTMUSP00000025884 VEGA | MGI Sequence Detail 1104 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(18) UniProt(5)
Polymorphisms SNPs within 2kb(235 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000012246 partner and localizer of BRCA2
References (Earliest) J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
(Latest) J:203561 Huo Y, et al., Autophagy opposes p53-mediated tumor barrier to facilitate tumorigenesis in a model of PALB2-associated hereditary breast cancer. Cancer Discov. 2013 Aug;3(8):894-907
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory